Department of Chemistry, 111 College Place, Syracuse University, Syracuse, NY 13244, USA.
Balchem Corporation, 52 Sunrise Park Road, New Hampton, NY 10958, USA.
Molecules. 2021 Apr 21;26(9):2419. doi: 10.3390/molecules26092419.
Magnesium (Mg) plays a crucial role in over 80% of all metabolic functions. It is becoming increasingly apparent that magnesium deficiency (hypomagnesemia) may play an important role in chronic disease. To counteract magnesium deficiency, there is an unmet clinical need to develop new fully characterized, highly bioavailable, and substantially water-soluble magnesium supplements. To this end, triglycine (HG), a tripeptide of the amino acid glycine, was chosen as a chelating ligand for magnesium, given its natural occurrence and water solubility, and entropically-driven metal binding. Herein, we discuss the synthesis, chemical and physical characterization, and cellular uptake of a magnesium triglycine chelate (MgG), an octahedral complex with extraordinary water solubility and improved cellular uptake in CaCo-2 cells than select commonly used magnesium supplements.
镁（Mg）在超过 80%的所有代谢功能中都起着至关重要的作用。越来越明显的是，镁缺乏（低镁血症）可能在慢性疾病中发挥重要作用。为了对抗镁缺乏，临床需要开发新的完全特征化、高生物利用度和高水溶性的镁补充剂。为此，三肽甘氨酸（HG）被选为镁的螯合剂，因为它天然存在且水溶性好，并且熵驱动的金属结合。在此，我们讨论了镁三肽螯合物（MgG）的合成、化学和物理特性以及细胞摄取，该螯合物具有非凡的水溶性，并且在 CaCo-2 细胞中的摄取率高于几种常用的镁补充剂。
