Matsuo T, Kurahashi Y, Nishida S, Kumada K, Hayami T, Takagi T
Gan To Kagaku Ryoho. 1987 May;14(5 Pt 1):1310-4.
C57BL mice were injected intravenously with an antitumor immunopotentiating polysaccharide, lentinan, to assess its effect on granulopoiesis in normal mice as well as its ability to enhance the recovery from leukopenia induced by 5-fluorouracil (5-FU). Lentinan increased neutrophils and monocytes in peripheral blood as well as granulocyte-macrophage progenitor cells (GM-CFC) in spleen and bone marrow. Administration of 5-FU induced a significant decrease in GM-CFC from day 1 to day 6, and thereafter the number of GM-CFC rebounded. The administration of 5-FU also suppressed white blood cells such as neutrophils, monocytes and lymphocytes. Injection of lentinan one day after 5-FU resulted in prompt restoration of the leukopenia through the recovery of neutrophils, monocytes and lymphocytes as well as prompt and marked rebound of GM-CFC. These results suggest that lentinan may contribute to the recovery from some of the hematopoietic depression in clinical chemoimmunotherapy.
将抗肿瘤免疫增强多糖香菇多糖静脉注射到C57BL小鼠体内，以评估其对正常小鼠粒细胞生成的影响，以及增强由5-氟尿嘧啶（5-FU）诱导的白细胞减少症恢复的能力。香菇多糖增加了外周血中的中性粒细胞和单核细胞，以及脾脏和骨髓中的粒细胞-巨噬细胞祖细胞（GM-CFC）。从第1天到第6天，5-FU的给药导致GM-CFC显著减少，此后GM-CFC的数量反弹。5-FU的给药还抑制了中性粒细胞、单核细胞和淋巴细胞等白细胞。在5-FU给药一天后注射香菇多糖，通过中性粒细胞、单核细胞和淋巴细胞的恢复以及GM-CFC的迅速显著反弹，导致白细胞减少症迅速恢复。这些结果表明，香菇多糖可能有助于临床化学免疫治疗中某些造血抑制的恢复。
