Matsuo T, Nishida S, Kumada K, Onodera C, Hayami T, Takagi T
Gan To Kagaku Ryoho. 1987 May;14(5 Pt 1):1305-9.
The effect of lentinan on granulopoiesis in BALB/c nude mice (Nu/Nu) was compared with that in their heterozygotes (Nu/+). Lentinan-injected Nu/+ showed enhanced serum colony-stimulating activity (CSA), and increased diphasically granulocyte-macrophage colony forming cells (GM-CFC) in bone marrow and spleen (i.e., first peak on day 1-2 and second peak on day 6). On the other hand, in Nu/Nu, lentinan did not enhance serum CSA, although the control level was higher than the enhanced level in Nu/+. Monophasic increase in GM-CFC was observed in Nu/Nu, but the second peak seen in Nu/+ was not observed. Reconstitution of Nu/+ splenocytes to Nu/Nu increased GM-CFC on day 6, and the increase was augmented by lentinan administration. These results suggest that mature T-cells participate in regulation of granulopoiesis in vivo and that lentinan augments granulopoiesis at least in part via mature T-cell populations.
将香菇多糖对BALB/c裸鼠（Nu/Nu）粒细胞生成的影响与其杂合子（Nu/+）进行比较。注射香菇多糖的Nu/+血清集落刺激活性（CSA）增强，骨髓和脾脏中的双相粒细胞-巨噬细胞集落形成细胞（GM-CFC）增加（即第1-2天出现第一个峰值，第6天出现第二个峰值）。另一方面，在Nu/Nu中，香菇多糖虽未增强血清CSA，但其对照水平高于Nu/+中的增强水平。在Nu/Nu中观察到GM-CFC呈单相增加，但未观察到Nu/+中出现的第二个峰值。将Nu/+脾细胞重建到Nu/Nu中可使第6天的GM-CFC增加，且香菇多糖给药可增强这种增加。这些结果表明，成熟T细胞参与体内粒细胞生成的调节，且香菇多糖至少部分通过成熟T细胞群体增强粒细胞生成。
