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获得信息:儿童和青少年轻微骨科损伤的阿片类药物处方呈下降趋势。

Getting the Message: The Declining Trend in Opioid Prescribing for Minor Orthopaedic Injuries in Children and Adolescents.

机构信息

Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Division of Orthopaedics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.

出版信息

J Bone Joint Surg Am. 2022 Jul 6;104(13):1166-1171. doi: 10.2106/JBJS.21.01078. Epub 2022 Mar 24.

Abstract

BACKGROUND

Opioids constitute the fastest-growing drug problem among children and adolescents in the United States. Recent heavy media coverage on the opioid prescription epidemic has garnered increased attention from prescribers and policymakers. The purpose of this study was to analyze trends in opioid prescribing for nonoperatively managed pediatric fractures and dislocations in order to examine changes in opioid-prescribing patterns across various U.S. regions.

METHODS

A retrospective review of the national Pediatric Health Information System (PHIS) database comprising 42 pediatric hospitals was performed to identify pediatric fractures and dislocations presenting to the emergency department (ED) or outpatient clinics from 2004 to 2017. We included patients with the 10 most frequently encountered diagnoses who were nonoperatively managed and were discharged home the same day. To account for hospital variation, we utilized a mixed-effects logistic regression model.

RESULTS

The final cohort included 134,931 patients, with a mean age (and standard deviation) of 12.57 ± 2.00 years (range, 10 to 18 years); 69.23% of patients were male. Overall, 51.69% of patients were prescribed at least 1 opioid dose during their ED or clinic visits. Of the patients receiving opioids, 72.04% were male and 54.10% were insured through a private insurance plan. When prescription trends were compared according to regions, children were more likely to be prescribed opioids in the South (71.37% more likely) and the Midwest (26.17% more likely) than in the Northeast.

CONCLUSIONS

Although the opioid prescription rates in all 4 regions have decreased dramatically over the years, some regions were quicker than others in responding to the opioid epidemic. A significant interregional variability in opioid-prescribing practices still exists, but an overall downward trend in opioid prescription rates for acute pain management in conservatively treated pediatric fractures and dislocations is evidence of progress in tackling the opioid crisis.

CLINICAL RELEVANCE

Opioid-related misuse is a national epidemic and reducing the use of opioids in pediatric orthopaedic procedures is critical. Although regional variability in opioid-prescribing practices still exists, an overall downward trend in opioid prescription rates for acute pain management in conservatively treated pediatric fractures and dislocations is evidence of progress in tackling the opioid crisis.

摘要

背景

阿片类药物是美国儿童和青少年中增长最快的药物问题。最近媒体对阿片类药物处方泛滥的大量报道引起了处方医生和决策者的更多关注。本研究的目的是分析非手术治疗儿童骨折和脱位的阿片类药物处方趋势,以研究美国不同地区阿片类药物处方模式的变化。

方法

对全国儿科健康信息系统(PHIS)数据库进行回顾性分析,该数据库包含 42 家儿童医院,从 2004 年至 2017 年期间,共纳入了 10 种最常见诊断的急诊或门诊就诊的儿童骨折和脱位患者。我们纳入了当天出院的非手术治疗的患者。为了考虑医院差异,我们使用了混合效应逻辑回归模型。

结果

最终纳入了 134931 名患者,平均年龄(标准差)为 12.57±2.00 岁(范围 10 至 18 岁);69.23%的患者为男性。总体而言,51.69%的患者在急诊或就诊期间至少开具了 1 剂阿片类药物。在接受阿片类药物治疗的患者中,72.04%为男性,54.10%通过私人保险计划投保。根据地区比较处方趋势,与东北地区相比,南部(71.37%更有可能)和中西部(26.17%更有可能)的儿童更有可能被开具阿片类药物。

结论

尽管所有 4 个地区的阿片类药物处方率多年来都大幅下降,但一些地区对阿片类药物流行的反应速度比其他地区更快。阿片类药物处方实践仍存在显著的地区间差异,但保守治疗的儿童骨折和脱位急性疼痛管理中阿片类药物处方率的总体下降趋势表明,在应对阿片类药物危机方面取得了进展。

临床意义

阿片类药物相关滥用是一个全国性的流行病,减少儿童骨科手术中阿片类药物的使用至关重要。尽管阿片类药物处方实践的地区差异仍然存在,但保守治疗的儿童骨折和脱位急性疼痛管理中阿片类药物处方率的总体下降趋势表明,在应对阿片类药物危机方面取得了进展。

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