Department of Internal Medicine, Crozer-Chester Medical Center, Upland, PA, USA.
Department of Ophthalmology, Harvard Medical School, Boston, MA, USA
BMJ Case Rep. 2022 Jul 6;15(7):e250662. doi: 10.1136/bcr-2022-250662.
Atezolizumab is a humanised monoclonal IgG1 antibody that is used in treating many solid malignancies. Endocrinopathies are known but a rare adverse event of these immunotherapeutic drugs. Autoimmune diabetes induced by atezolizumab has been rarely reported in the literature. We report the case of a woman in her eighth decade with no known history of diabetes who developed new-onset autoimmune diabetes and Takotsubo cardiomyopathy due to the adverse effects of atezolizumab therapy for hepatocellular carcinoma. We also review the characteristics and outcomes of cases previously reported in the literature.
阿特珠单抗是一种人源化单克隆 IgG1 抗体，用于治疗许多实体恶性肿瘤。已知会发生内分泌疾病，但这些免疫治疗药物的罕见不良反应。阿特珠单抗引起的自身免疫性糖尿病在文献中很少报道。我们报告了一例 80 多岁的女性，无已知糖尿病史，因肝细胞癌的阿特珠单抗治疗的不良反应而发生新发自身免疫性糖尿病和 Takotsubo 心肌病。我们还回顾了文献中先前报道的病例的特征和结局。
