• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

免疫检查点抑制剂相关应激性心肌病：鉴别诊断及心脏成像的关键作用

Immune Checkpoint Inhibitor-Related Stress Cardiomyopathy: Differential Diagnosis and Key Role of Cardiac Imaging.

作者信息

Cobarro Lucía, Valbuena-López Silvia, Contreras Cristina, Ugueto Clara, Ruiz-Gutiérrez Iciar, Peña-López Jesús, Ruiz-Giménez Leticia, López-Fernández Teresa

机构信息

Department of Cardiology, La Paz University Hospital, Madrid, Spain.

Department of Oncology, La Paz University Hospital, Madrid, Spain.

出版信息

JACC Case Rep. 2023 Jun 21;16:101881. doi: 10.1016/j.jaccas.2023.101881.

DOI:10.1016/j.jaccas.2023.101881
PMID:37396332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10313486/
Abstract

A 76-year-old man with stage IV urothelial carcinoma who was receiving atezolizumab presented with dyspnea, elevated cardiac biomarkers, new negative T waves, and left ventricular apical akinesia. Coronary angiography results were normal. Immune checkpoint inhibitor-related myocarditis was suspected, and high-dose corticosteroid treatment was started. Cardiac magnetic resonance showed apical edema, suggesting stress cardiomyopathy. ().

摘要

一名76岁的IV期尿路上皮癌男性患者正在接受阿替利珠单抗治疗，出现呼吸困难、心脏生物标志物升高、新出现的T波倒置和左心室心尖运动减弱。冠状动脉造影结果正常。怀疑为免疫检查点抑制剂相关的心肌炎，并开始了大剂量皮质类固醇治疗。心脏磁共振显示心尖水肿，提示应激性心肌病。（）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/883e/10313486/97ad25f34892/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/883e/10313486/8c3bfcd310cd/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/883e/10313486/3ebd15355024/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/883e/10313486/97ad25f34892/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/883e/10313486/8c3bfcd310cd/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/883e/10313486/3ebd15355024/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/883e/10313486/97ad25f34892/gr2.jpg

相似文献

1
Immune Checkpoint Inhibitor-Related Stress Cardiomyopathy: Differential Diagnosis and Key Role of Cardiac Imaging.免疫检查点抑制剂相关应激性心肌病：鉴别诊断及心脏成像的关键作用
JACC Case Rep. 2023 Jun 21;16:101881. doi: 10.1016/j.jaccas.2023.101881.
2
Left ventricular myocardial strain and tissue characterization by cardiac magnetic resonance imaging in immune checkpoint inhibitor associated cardiotoxicity.心脏磁共振成像在免疫检查点抑制剂相关性心脏毒性中心肌应变和组织特征的研究。
PLoS One. 2021 Feb 19;16(2):e0246764. doi: 10.1371/journal.pone.0246764. eCollection 2021.
3
A case of lymphocytic myocarditis in a patient treated with an immune checkpoint inhibitor, a recent class of chemotherapy agents.免疫检查点抑制剂是一类新型化疗药物，本文报告了 1 例使用免疫检查点抑制剂治疗的淋巴细胞性心肌炎患者。
Rev Port Cardiol. 2022 Dec;41(12):1047-1051. doi: 10.1016/j.repc.2019.03.013. Epub 2022 Oct 15.
4
Takotsubo-like syndrome triggered by fludrocortisone overdose for Addison's disease: a case report.氟氢可的松过量引发的艾迪生病类Takotsubo综合征：一例病例报告
J Med Case Rep. 2016 Oct 12;10(1):281. doi: 10.1186/s13256-016-1074-5.
5
Case of pembrolizumab-induced myocarditis presenting as torsades de pointes with safe re-challenge.帕博利珠单抗诱发的心肌炎表现为尖端扭转型室速且成功再次激发的病例。
J Oncol Pharm Pract. 2020 Sep;26(6):1544-1548. doi: 10.1177/1078155220904152. Epub 2020 Feb 23.
6
Acute cardiac manifestations under immune checkpoint inhibitors-beware of the obvious: a case report.免疫检查点抑制剂治疗下的急性心脏表现——警惕明显症状：一例病例报告
Eur Heart J Case Rep. 2021 Aug 12;5(8):ytab262. doi: 10.1093/ehjcr/ytab262. eCollection 2021 Aug.
7
Ga-DOTATOC PET/CT to detect immune checkpoint inhibitor-related myocarditis.Ga-DOTATOC PET/CT 检测免疫检查点抑制剂相关心肌炎。
J Immunother Cancer. 2021 Oct;9(10). doi: 10.1136/jitc-2021-003594.
8
Refractory right ventricular myocarditis induced by immune checkpoint inhibitor despite therapy cessation and immune suppression.尽管停用了免疫检查点抑制剂并进行了免疫抑制治疗，但仍发生难治性右心室心肌炎。
Cardiooncology. 2023 Mar 20;9(1):15. doi: 10.1186/s40959-023-00165-2.
9
Takotsubo cardiomyopathy and transient thyrotoxicosis during combination therapy with interferon-alpha and ribavirin for chronic hepatitis C.慢性丙型肝炎干扰素-α和利巴韦林联合治疗期间出现 Takotsubo 心肌病和短暂甲状腺毒症。
BMC Endocr Disord. 2014 Feb 3;14:10. doi: 10.1186/1472-6823-14-10.
10
Myocarditis in a patient treated with Nivolumab and PROSTVAC: a case report.尼妥珠单抗联合 PROSTVAC 治疗后发生心肌炎 1 例报告
J Immunother Cancer. 2018 Dec 18;6(1):150. doi: 10.1186/s40425-018-0473-0.

本文引用的文献

1
Takotsubo syndrome in a patient with metastatic renal cell carcinoma treated with pembrolizumab plus axitinib.帕博利珠单抗联合阿昔替尼治疗转移性肾细胞癌患者发生 Takotsubo 综合征。
Immunotherapy. 2022 Nov;14(16):1297-1305. doi: 10.2217/imt-2022-0013. Epub 2022 Nov 21.
2
2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS).2022年欧洲心脏病学会（ESC）与欧洲血液学协会（EHA）、欧洲治疗放射学与肿瘤学协会（ESTRO）以及国际心脏肿瘤学会（IC-OS）合作制定的心脏肿瘤学指南。
Eur Heart J. 2022 Nov 1;43(41):4229-4361. doi: 10.1093/eurheartj/ehac244.
3
Atezolizumab-induced autoimmune diabetes mellitus presenting as diabetic ketoacidosis and Takotsubo cardiomyopathy.
阿特珠单抗引起的自身免疫性糖尿病，表现为糖尿病酮症酸中毒和 Takotsubo 心肌病。
BMJ Case Rep. 2022 Jul 6;15(7):e250662. doi: 10.1136/bcr-2022-250662.
4
Cardiac Toxicity Associated with Immune Checkpoint Inhibitors: A Systematic Review.免疫检查点抑制剂相关的心脏毒性：一项系统评价。
Cancers (Basel). 2021 Oct 18;13(20):5218. doi: 10.3390/cancers13205218.
5
Takotsubo Cardiomyopathy Associated With Checkpoint Inhibitor Therapy: Endomyocardial Biopsy Provides Pathological Insights to Dual Diseases.与检查点抑制剂治疗相关的应激性心肌病：心内膜心肌活检为两种疾病提供病理见解
JACC CardioOncol. 2021 Jun 15;3(2):330-334. doi: 10.1016/j.jaccao.2021.02.005. eCollection 2021 Jun.
6
Cardiotoxicity of Immune Checkpoint Inhibitors.免疫检查点抑制剂的心脏毒性。
Curr Oncol Rep. 2021 May 3;23(7):79. doi: 10.1007/s11912-021-01070-6.
7
Immune checkpoint inhibitor-induced takotsubo syndrome and diabetic ketoacidosis: rare reactions.免疫检查点抑制剂引起的 Takotsubo 综合征和糖尿病酮症酸中毒：罕见反应。
BMJ Case Rep. 2021 Feb 1;14(2):e237217. doi: 10.1136/bcr-2020-237217.
8
Concomitant myopericarditis and takotsubo syndrome following immune checkpoint inhibitor therapy.免疫检查点抑制剂治疗后并发心肌炎和心尖球形综合征。
BMJ Case Rep. 2020 Sep 2;13(9):e235265. doi: 10.1136/bcr-2020-235265.
9
Takotsubo syndrome in patients with cancer treated with immune checkpoint inhibitors: a new adverse cardiac complication.接受免疫检查点抑制剂治疗的癌症患者中的应激性心肌病：一种新的不良心脏并发症。
Eur J Heart Fail. 2019 Jul;21(7):945-947. doi: 10.1002/ejhf.1497.
10
Stress Cardiomyopathy Diagnosis and Treatment: JACC State-of-the-Art Review.应激性心肌病的诊断与治疗：美国心脏病学会心血管造影及介入治疗学会最新临床观点。
J Am Coll Cardiol. 2018 Oct 16;72(16):1955-1971. doi: 10.1016/j.jacc.2018.07.072.