Department of Prosthodontics, Faculty of Dentistry, Chulalongkorn University.
Biomaterial Testing Center, Faculty of Dentistry, Chulalongkorn University.
Dent Mater J. 2022 Oct 2;41(5):757-766. doi: 10.4012/dmj.2022-005. Epub 2022 Jul 6.
The important factors contributing to the effectiveness of fluoride varnish are the amount of fluoride ion release and the retention time of the varnish on the tooth surface. Commercial fluoride varnishes are susceptible to mechanical removal; therefore, patients are informed to avoid eating or performing oral hygiene for at least 12-24 h, which results in patient inconvenience. However, cyanoacrylate-based fluoride varnish would not have these disadvantages. This study compared the daily fluoride ion release, abrasion resistance to brushing, and toxicity to human gingival fibroblasts (hGFs) between a newly-developed cyanoacrylate-based fluoride varnish and conventional fluoride varnish (Duraphat varnish). The results demonstrated that the cyanoacrylate varnish had a significantly higher fluoride release for 9 days after application, higher abrasion resistance to brushing, and slightly less toxicity to hGFs compared with Duraphat varnish. This novel cyanoacrylate varnish could be an alternative fluoride varnish for preventing dental caries.
促进氟漆有效性的重要因素是氟离子的释放量和氟漆在牙齿表面的保持时间。商业氟漆容易受到机械性的去除；因此，告知患者至少在 12-24 小时内避免进食或进行口腔卫生，这给患者带来了不便。然而，氰基丙烯酸酯基氟漆则没有这些缺点。本研究比较了一种新开发的氰基丙烯酸酯基氟漆与传统氟漆（Duraphat 氟漆）之间的每日氟离子释放、耐刷牙磨损性和对人牙龈成纤维细胞（hGFs）的毒性。结果表明，与 Duraphat 氟漆相比，氰基丙烯酸酯漆在使用后 9 天内具有更高的氟释放量、更高的耐刷牙磨损性和略低的 hGFs 毒性。这种新型氰基丙烯酸酯漆可能是预防龋齿的一种替代氟漆。
