Department of Pathology, Nanjing Medical University Affiliated Wuxi Second Hospital.
Department of Ophthalmology, Nanjing Medical University Affiliated Wuxi Second Hospital.
Tohoku J Exp Med. 2022 Aug 6;258(1):43-48. doi: 10.1620/tjem.2022.J054. Epub 2022 Jul 7.
Amyloidosis is characterized by systemic or local deposition of amyloid fibrils outside organs and tissues. Amyloidosis is rarely seen on cornea. A 30-year-old woman patient had had trichiasis in both eyes for 8 years. Trichiasis was observed, which touched the cornea. Slit lamp microscopy showed white gelatinous droplet-like eminences and trichiasis in the lower cornea of the right eye. Optical coherence tomography showed that the lesion involved most of the cornea. Hematoxylin and eosin staining showed that most of the stroma stained red, with scattered inflammatory cells. High expression of lactoferrin was detected by mass spectrometry, and the case was diagnosed as secondary corneal lactoferrin amyloidosis in the right eye.
淀粉样变性的特征是器官和组织外的淀粉样纤维的全身或局部沉积。角膜很少见淀粉样变性。一位 30 岁的女性患者双眼患有 8 年的倒睫。观察到倒睫触及角膜。裂隙灯显微镜检查显示右眼下角膜有白色胶状滴状隆起和倒睫。光学相干断层扫描显示病变累及大部分角膜。苏木精-伊红染色显示大部分基质呈红色，伴有散在的炎症细胞。质谱检测显示乳铁蛋白高表达，诊断为右眼继发性角膜乳铁蛋白淀粉样变性。
