Division of Otolaryngology, Tohoku Medical and Pharmaceutical University Hospital.
Department of Otolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine.
Tohoku J Exp Med. 2022 Aug 9;258(1):55-62. doi: 10.1620/tjem.2022.J055. Epub 2022 Jul 7.
Long-term voice abuse or sudden vocal fold microvascular disruption may lead to injury and subsequent repair/remodeling in the vocal fold mucosa. Periostin is known to be involved in airway remodeling and also in various otolaryngological diseases. The aim of this article was to investigate the expression and the role of periostin in the formation of vocal fold polyps. The expression patterns of periostin in 59 surgical specimens of vocal fold polyps from 54 patients were investigated immunohistochemically. Normal vocal fold mucosa specimens from 5 patients who had undergone total laryngectomy were used as the control group. Retrospective study with planned data collection was conducted at Tohoku Medical and Pharmaceutical University. Expression of periostin was detected in 43 (72.9%) samples and four patterns of periostin expression were observed in vocal fold polyps: negative type, superficial type, infiltrative type, and diffuse type. An association was observed between periostin expression patterns and the histological subtypes of vocal fold polyps. The infiltrative pattern of periostin expression was significantly dominant in vascular-hyaline types. Expression of transforming growth factor-β (TGF-β) was also detected in the vocal fold polyps. Our results confirmed that periostin might be involved in certain pathological changes in vocal fold polyps, such as extracellular matrix accumulation, local fibrosis, and formation and development of vocal fold polyps.
长期的声带滥用或声带微小血管突然破裂可能导致声带黏膜损伤和随后的修复/重塑。骨膜蛋白已知参与气道重塑以及各种耳鼻喉疾病。本文旨在研究骨膜蛋白在声带息肉形成中的表达和作用。通过免疫组织化学方法研究了 54 例患者的 59 个声带息肉手术标本中骨膜蛋白的表达模式。将 5 例因全喉切除术而接受治疗的患者的正常声带黏膜标本作为对照组。在东北医科大学进行了计划数据收集的回顾性研究。在 43 例（72.9％）标本中检测到骨膜蛋白的表达，并在声带息肉中观察到四种骨膜蛋白表达模式：阴性型、浅表型、浸润型和弥漫型。骨膜蛋白表达模式与声带息肉的组织学亚型之间存在关联。浸润型骨膜蛋白表达在血管透明质样型中明显占主导地位。在声带息肉中还检测到转化生长因子-β（TGF-β）的表达。我们的结果证实，骨膜蛋白可能参与声带息肉的某些病理变化，如细胞外基质积累、局部纤维化以及声带息肉的形成和发展。
