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内科胸腔镜术后胸腔内注射尿激酶治疗脓胸和复杂性类肺炎性胸腔积液：病例系列研究。

Intrapleural Urokinase Injection after Medical Thoracoscopy for Empyema and Complicated Para-Pneumonic Effusion: A Case Series.

机构信息

Department of Respiratory Medicine, Nagoya Tokushukai General Hospital, Japan.

Department of Respiratory Medicine and Allergology, Aichi Medical University, Japan.

出版信息

Intern Med. 2023 Feb 15;62(4):571-576. doi: 10.2169/internalmedicine.0060-22. Epub 2022 Jul 5.

DOI:10.2169/internalmedicine.0060-22
PMID:35793957
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10017240/
Abstract

Empyema and complicated para-pneumonic effusion (CPPE) often require surgical intervention because of insufficient antibiotic effect and chest tube drainage. From January 2017 to September 2021, we encountered seven patients who underwent intrapleural urokinase injection after medical thoracoscopy for the treatment of empyema or CPPE. None of the seven patients required further surgical interventions or showed any complications associated with the therapeutic procedures. The combined use of intrapleural urokinase injections and medical thoracoscopy may be an effective and safe therapeutic option for the management of empyema and CPPE.

摘要

脓胸和复杂性肺炎旁胸腔积液（CPPE）常因抗生素疗效不佳和胸腔引流管引流不充分而需要手术干预。自 2017 年 1 月至 2021 年 9 月，我们遇到了 7 例在胸腔镜检查后接受胸腔内尿激酶注射治疗脓胸或 CPPE 的患者。这 7 例患者均无需进一步手术干预，也未出现与治疗过程相关的任何并发症。胸腔内尿激酶注射联合胸腔镜检查可能是治疗脓胸和 CPPE 的一种有效且安全的治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4585/10017240/876783405298/1349-7235-62-0571-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4585/10017240/322ad45a76e7/1349-7235-62-0571-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4585/10017240/876783405298/1349-7235-62-0571-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4585/10017240/322ad45a76e7/1349-7235-62-0571-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4585/10017240/876783405298/1349-7235-62-0571-g002.jpg

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Medical thoracoscopy treatment for pleural infections: a systematic review and meta-analysis.胸腔镜治疗胸膜感染：一项系统评价和荟萃分析
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胸腔内单独应用尿激酶与胸腔感染患者治疗失败的相关性：一项回顾性队列研究。
BMC Pulm Med. 2023 Jul 21;23(1):273. doi: 10.1186/s12890-023-02559-5.
中国医学胸腔镜诊断与治疗专家共识
J Thorac Dis. 2020 May;12(5):1799-1810. doi: 10.21037/jtd-19-2276.
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Intrapleural Fibrinolytic Therapy versus Early Medical Thoracoscopy for Treatment of Pleural Infection. Randomized Controlled Clinical Trial.胸腔内纤维蛋白溶解治疗与早期内科胸腔镜治疗胸腔感染。随机对照临床试验。
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