Institute of Nutritional Medicine, University of Hohenheim, 70599 Stuttgart, Germany.
Institute of Nutritional Medicine, University of Hohenheim, 70599 Stuttgart, Germany.
Trends Mol Med. 2022 Dec;28(12):1070-1081. doi: 10.1016/j.molmed.2022.06.003. Epub 2022 Jul 4.
Epidemiologic studies show both positive and negative associations between allergies and cancer. Allergic diseases may protect against tumorigenesis by promoting the immune surveillance, while carcinogenesis may be promoted through inflammatory responses from allergies. Histamine receptor antagonists are the focus of recent cancer studies because of their promising beneficial effect on tumor development. Also, cytokines, particularly IL-4 or IL-33, IgE as well as allergy-related immune cells such as eosinophils can contribute to tumor growth suppression. Depending on cancer types, cancer therapy may be more beneficial when considering combinatorial immunotherapy. In this review, we give an overview on molecular links between allergies and cancer.
流行病学研究表明，过敏和癌症之间存在正相关和负相关两种关系。过敏疾病可能通过促进免疫监视来预防肿瘤发生，而肿瘤发生也可能通过过敏的炎症反应来促进。由于组胺受体拮抗剂对肿瘤发展具有良好的有益作用，因此成为癌症研究的焦点。此外，细胞因子（特别是 IL-4 或 IL-33）、IgE 以及与过敏相关的免疫细胞（如嗜酸性粒细胞）也可以促进肿瘤生长抑制。根据癌症类型，在考虑联合免疫疗法时，癌症治疗可能会更有益。在这篇综述中，我们概述了过敏和癌症之间的分子联系。
