Hellman Lars
Department of Cell and Molecular Biology, BMC, Box 596, 751 24 Uppsala, Sweden.
Expert Rev Vaccines. 2008 Mar;7(2):193-208. doi: 10.1586/14760584.7.2.193.
Therapeutic vaccines targeting various self-molecules is an emerging field of vaccine development that is studied extensively in areas such as birth control, cancer, allergy and autoimmunity. Promising results have come from a number of animal studies and several vaccines are in advanced clinical trials. However, no vaccine is currently on the market. This review will focus on the progress in the development of vaccines against IgE-mediated allergies. Targets under investigation are the IgE molecule itself and several Th2 cytokines, that is, IL-4, -5, -13, -33, -18 and thymic stromal lymphopoietin. This review will also discuss new methods to enhance the immunogenicity of the vaccines and how this can contribute to more rapid progress in the field.
针对各种自身分子的治疗性疫苗是疫苗研发的一个新兴领域，在避孕、癌症、过敏和自身免疫等领域得到了广泛研究。许多动物研究已取得了有前景的结果，几种疫苗正处于晚期临床试验阶段。然而，目前尚无疫苗上市。本综述将聚焦于抗IgE介导过敏疫苗的研发进展。正在研究的靶点是IgE分子本身以及几种Th2细胞因子，即白细胞介素-4、-5、-13、-33、-18和胸腺基质淋巴细胞生成素。本综述还将讨论增强疫苗免疫原性的新方法，以及这如何有助于该领域取得更快进展。
