Gansu Provincial Maternity and Child Care Hospital, 143 North Road Qilihe District, Lanzhou, 730050, Gansu Province, China.
Biol Trace Elem Res. 2023 May;201(5):2191-2199. doi: 10.1007/s12011-022-03338-9. Epub 2022 Jul 6.
The incidence of congenital heart diseases (CHDs) shows an increasing trend and results in large health burdens in China. However, there have been inconsistent results of the relationship between lead (Pb) level and risk of CHDs. We performed a pair-matched case-control study and included 97 cases and 194 controls to investigate the association between pregnancy Pb exposure and the risk of CHDs in a birth cohort study conducted in Lanzhou, China. The results showed that compared to the lowest Pb tertile, both highest tertile levels of maternal blood and umbilical cord blood Pb were associated with an increased risk of CHDs. The similar significant results were found in cases with isolated CHDs. Compared to both lowest tertiles of Pb level in maternal blood and umbilical cord blood, the highest tertile was associated with an increased risk of CHDs, especially for isolated CHDs. Overall, our study suggests a significant association between pregnancy Pb exposure and risk of CHDs, especially for isolated CHDs. Future studies are needed to elucidate the underlying mechanism.
先天性心脏病（CHD）的发病率呈上升趋势，给中国带来了巨大的健康负担。然而，铅（Pb）水平与 CHD 风险之间的关系结果并不一致。我们进行了一项配对病例对照研究，纳入了 97 例病例和 194 例对照，以调查在中国兰州进行的出生队列研究中妊娠铅暴露与 CHD 风险之间的关系。结果表明，与最低铅三分位相比，母体血和脐血的最高铅三分位水平均与 CHD 风险增加相关。在单纯性 CHD 病例中也发现了类似的显著结果。与母体血和脐血的最低铅三分位相比，最高铅三分位与 CHD 风险增加相关，尤其是单纯性 CHD。总体而言，我们的研究表明妊娠铅暴露与 CHD 风险之间存在显著关联，尤其是单纯性 CHD。未来需要进一步的研究来阐明其潜在机制。
