Jin Lin-Yu, Su Xin-Jin, Xu Shuai, Liu Hai-Ying, Li Xin-Feng
Department of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, People's Republic of China.
Department of Orthopedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Int J Gen Med. 2022 Jun 30;15:5869-5877. doi: 10.2147/IJGM.S368718. eCollection 2022.
Hounsfield Unit (HU) has been used to investigate the asymmetrical vertebral bone mass in patients associated with adult degenerative scoliosis (ADS). Therefore, there is an inevitable need to evaluate the performance of HU values in ADS subjects.
A total of 162 patients (81 ADS patients and 81 non-ADS patients) aged ≥50 years undergoing the CT examination were reviewed. The HU values of the lumbar vertebral body (including total, convex side, and concave side) at bilateral pedicle plane were obtained and compared. The paired -test, chi-squared test, independent samples -test, and interclass correlation coefficient (ICC) were used for statistical analyses.
The HU values were significantly different between the convex and concave sides of the lumbar vertebral body (P < 0.01). The total prevalence of osteoporosis (OP) in ADS patients was higher than that of non-ADS patients. The prevalence of OP in female or male of ADS patients was higher than that of non-ADS patients, respectively. Intra- and inter-rater reliability were very strong (both >0.8) for measuring asymmetrical vertebral bone mass in ADS patients.
HU value was a high reproducibility method for evaluating the vertebral bone mass in ADS patients. The HU values at the concave sides were significantly higher than that of convex sides at the lumbar vertebral body on the pedicle plane. The prevalence of OP in ADS patients was higher than that of non-ADS patients, especially for females associated with ADS. Moreover, the static asymmetric load did not enhance the bone mass at the concave side compared with the left/right side of non-ADS patients.
亨氏单位（HU）已被用于研究与成人退变性脊柱侧凸（ADS）相关患者的不对称椎体骨量。因此，不可避免地需要评估ADS患者中HU值的表现。
回顾了162例年龄≥50岁接受CT检查的患者（81例ADS患者和81例非ADS患者）。获取并比较双侧椎弓根平面腰椎椎体（包括整体、凸侧和凹侧）的HU值。采用配对t检验、卡方检验、独立样本t检验和组内相关系数（ICC）进行统计分析。
腰椎椎体凸侧和凹侧的HU值存在显著差异（P<0.01）。ADS患者骨质疏松症（OP）的总体患病率高于非ADS患者。ADS患者中女性和男性的OP患病率分别高于非ADS患者。在测量ADS患者的不对称椎体骨量时，评分者内和评分者间的可靠性都很强（均>0.8）。
HU值是评估ADS患者椎体骨量的一种具有高重复性的方法。在椎弓根平面，腰椎椎体凹侧的HU值显著高于凸侧。ADS患者的OP患病率高于非ADS患者，尤其是患有ADS的女性。此外，与非ADS患者的左侧/右侧相比，静态不对称负荷并未增加凹侧的骨量。
