Nantong University, Nantong, Jiangsu, China.
Cancer Research Center Nantong, Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu, China.
Biomed Res Int. 2022 Jun 26;2022:4541571. doi: 10.1155/2022/4541571. eCollection 2022.
ZC3H12C is an important member of the CCCH-zinc finger protein family and is mainly involved in host immune and inflammatory diseases. However, its abnormal expression and prognostic value in cancer have not yet been established. Through comparative analysis of the Cancer Genome Atlas (TCGA) database, we found that ZC3H12C is the most relevant to the prognosis, grade, and stage of renal clear cell carcinoma (ccRCC) across 33 cancers. With the help of patient transcription and clinical data from the TCGA and GEO (GSE53757, GSE36895) databases, we determined that in the immune environment of patients with ccRCC, ZC3H12C was clearly negatively correlated with Tregs and was significantly positively correlated with monocytes. In addition, protein phosphorylation and DNA methylation analysis also showed that ZC3H12C negatively regulates the role of cancer in ccRCC. Our research may provide new insights into ccRCC immunotherapy and bring forth novel biomarkers and therapeutic targets.
ZC3H12C 是 CCCH-锌指蛋白家族的重要成员，主要参与宿主免疫和炎症性疾病。然而，其在癌症中的异常表达及其预后价值尚未确定。通过对癌症基因组图谱（TCGA）数据库的比较分析，我们发现 ZC3H12C 与 33 种癌症中肾透明细胞癌（ccRCC）的预后、分级和分期最相关。借助 TCGA 和 GEO（GSE53757、GSE36895）数据库的患者转录组和临床数据，我们确定在 ccRCC 患者的免疫环境中，ZC3H12C 与 Tregs 呈明显负相关，与单核细胞呈显著正相关。此外，蛋白质磷酸化和 DNA 甲基化分析也表明 ZC3H12C 负向调节 ccRCC 中的癌症作用。我们的研究可能为 ccRCC 的免疫治疗提供新的见解，并带来新的生物标志物和治疗靶点。
