Bai Ai-Mei, Li Qian, Li Yue, Fan Zhong-Xue, Li Xiao-Qian, Tan Wen-Hong, Cao Dong-Yuan, Kang Yi-Jun
Key Laboratory of Trace Elements and Endemic Diseases of the National Health Commission, Shaanxi Provincial Institute For Endemic Disease Control, Xi'an, China.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Research Center of Stomatology, Xi'an Jiaotong University College of Stomatology, Xi'an, China.
Front Nutr. 2022 Jun 20;9:922481. doi: 10.3389/fnut.2022.922481. eCollection 2022.
This study aims to explore whether selenium (Se) concentration correlates with arseniasis in a high-arsenic coal area in the southern Shaanxi Province, China. Herein, an epidemiological investigation was conducted among 100 arsenic (As)-poisoned patients in Ziyang County, an area with high soil As and Se levels. Fifty healthy subjects were selected from areas without endemic As poisoning. The subjects in the high-As coal area were diagnosed with either normal, suspicious, mild, moderate, or severe As poisoning. Local coal, water, soil, corn, and pepper samples, as well as hair, blood, and urine samples of subjects and patients were collected and analyzed for their As and Se contents. The contents of As and Se in coal, soil, corn, pepper, and hair samples from Ziyang County were significantly higher than those in the control area. The As content of hair in Ziyang County positively correlated with As poisoning, whereas the Se content of hair and urine negatively correlated with As poisoning. The Se content in the body was negatively correlated with the degree of As poisoning, indicating that Se may accelerate the metabolism and decumulation of As and antagonize As toxicity.
本研究旨在探讨中国陕西省南部高砷煤区硒（Se）浓度与砷中毒是否相关。在此，对紫阳县100名砷（As）中毒患者进行了流行病学调查，该地区土壤中砷和硒含量较高。从无地方性砷中毒地区选取了50名健康受试者。高砷煤区的受试者被诊断为正常、可疑、轻度、中度或重度砷中毒。采集了当地的煤、水、土壤、玉米和辣椒样本，以及受试者和患者的头发、血液和尿液样本，并分析了其中的砷和硒含量。紫阳县煤、土壤、玉米、辣椒和头发样本中的砷和硒含量显著高于对照地区。紫阳县头发中的砷含量与砷中毒呈正相关，而头发和尿液中的硒含量与砷中毒呈负相关。体内的硒含量与砷中毒程度呈负相关，表明硒可能加速砷的代谢和排泄，并拮抗砷的毒性。
