Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, Zhejiang 310006, P.R. China.
Int J Oncol. 2022 Aug;61(2). doi: 10.3892/ijo.2022.5388. Epub 2022 Jul 7.
Primary cilia are hair‑like organelles that are present on the majority of mammalian cells. They are regarded as the regulatory 'hub' of cell functions due to their indispensable roles for several signaling pathways, such as Hh and Wnt pathways. Originally, cilia defects were found to cause a panoply of human diseases commonly referred to as 'ciliopathies'. Evidence is accumulating that cilia defects are involved in the onset and development of cancer. Some proteins that cause cilia defects have been identified as oncogenes in multiple cancer types. Hence, understanding the pathways that cause cilia defects in cancer is of utmost importance for the development of novel cancer therapeutic targets. The present review article provides a critical overview of the molecular targets of primary cilia defects in cancer, and highlights their vast potential as therapeutic targets and novel biomarkers.
原发性纤毛是存在于大多数哺乳动物细胞上的毛发状细胞器。由于它们在几个信号通路（如 Hh 和 Wnt 通路）中不可或缺的作用，因此被认为是细胞功能的调节“中心”。最初，纤毛缺陷被发现会导致多种通常被称为“纤毛病”的人类疾病。越来越多的证据表明，纤毛缺陷与癌症的发生和发展有关。一些导致纤毛缺陷的蛋白质已被确定为多种癌症类型的致癌基因。因此，了解导致癌症中纤毛缺陷的途径对于开发新的癌症治疗靶点至关重要。本文综述了原发性纤毛缺陷在癌症中的分子靶点，并强调了它们作为治疗靶点和新型生物标志物的巨大潜力。
