Department of Chemistry, University of Delhi, Delhi-110007, India.
Ramjas College, Department of Chemistry, University of Delhi, Delhi-110007, India.
Chem Commun (Camb). 2022 Jul 26;58(60):8424-8427. doi: 10.1039/d2cc02781j.
The base-mediated anti-Markovnikov hydroamination of functionally varied styrenes with amino-substituted pyridine, quinoline, pyrimidine, pyrazine, and phenanthridine with excellent regioselectivity has been described. Double hydroamination was observed chemoselectively on the secondary amine, leaving the primary amine intact. Experimental evidence suggests that the proposed reaction involves the nucleophilic addition of the aminopyridyl radical onto vinyl arenes a single electron transfer.
本文描述了功能多样的苯乙烯与氨基取代的吡啶、喹啉、嘧啶、吡嗪和菲啶在碱基介导下反 Markovnikov 区域选择性氢胺化反应。在二级胺上观察到选择性的双氢胺化，而一级胺保持不变。实验证据表明，所提出的反应涉及氨基吡啶基自由基对乙烯基芳烃的亲核加成，即单电子转移。
