循环血管内皮生长因子在亚洲糖尿病视网膜病变中的诊断价值：一项系统评价与Meta分析

The Diagnostic Value of Circulating VEGF in Diabetic Retinopathy in Asia: A Systematic Review and Meta-analysis.

作者信息

Liu Xiaobing, Zhou Xiaoping, Song Weiqiong, Zeng Jiechun, Niu Xiuxiu, Meng Ran

机构信息

Department of Endocrinology, HuiDong People's Hospital, Huizhou, Guangdong, China.

Department of Ophthalmology, Chenzhou First People's Hospital, Chenzhou, Hunan, China.

出版信息

Ophthalmic Epidemiol. 2023 Jun;30(3):230-238. doi: 10.1080/09286586.2022.2088805. Epub 2022 Jul 7.

DOI:10.1080/09286586.2022.2088805

PMID:35796414

Abstract

PURPOSE

Vascular endothelial growth factor (VEGF) has obvious clinical value in diabetes, but the conclusions on the diagnostic value of diabetic retinopathy (DR) are not consistent. This study aims to comprehensively evaluate the accuracy of circulating VEGF in the diagnosis of DR in the Asian population by a method of meta-analysis.

METHODS

PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and China Wanfang Databases were searched for relevant studies on the diagnostic value of VEGF for DR in Asia up to November 2021. The pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and areas under the curve (AUC) were calculated by Stata 15.0 software.

RESULTS

After screening, eight eligible studies were enrolled, including 547 patients with DR. The results of the meta-analysis showed that the pooled DOR, sensitivity, specificity, PLR, and NLR were 31.67 (95%CI: 13.55 ~ 74.05), 0.86 (95%CI: 0.74 ~ 0.93), 0.84 (95%CI: 0.80 ~ 0.87), 5.33 (95%CI: 4.09 ~ 6.93), 0.17 (95%CI: 0.09 ~ 0.32), respectively. The AUC was 0.86 (95%CI: 0.82 ~ 0.89).

CONCLUSION

Circulating VEGF has a good diagnostic value in DR in the Asian population, with the potential to be an early diagnostic marker for DR.

摘要

目的

血管内皮生长因子（VEGF）在糖尿病中具有明显的临床价值，但关于糖尿病视网膜病变（DR）诊断价值的结论并不一致。本研究旨在通过荟萃分析方法全面评估循环VEGF在亚洲人群DR诊断中的准确性。

方法

检索PubMed、Cochrane图书馆、Embase、Web of Science、中国知网（CNKI）和中国万方数据库，查找截至2021年11月关于VEGF对亚洲DR诊断价值的相关研究。使用Stata 15.0软件计算合并敏感度、特异度、阳性似然比（PLR）、阴性似然比（NLR）、诊断比值比（DOR）和曲线下面积（AUC）。

结果

筛选后纳入8项合格研究，包括547例DR患者。荟萃分析结果显示，合并DOR、敏感度、特异度、PLR和NLR分别为31.67（95%CI：13.55～74.05）、0.86（95%CI：0.74～0.93）、0.84（95%CI：0.80～0.87）、5.33（95%CI：4.09～6.93）、0.17（95%CI：0.09～0.32）。AUC为0.86（95%CI：0.82～0.89）。