炎症生物标志物、多种疾病和生物老化。
Inflammatory biomarkers, multi-morbidity, and biologic aging.
机构信息
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota.
Department of Neurology, Mayo Clinic, Rochester, Minnesota.
出版信息
J Int Med Res. 2022 Jul;50(7):3000605221109393. doi: 10.1177/03000605221109393.
OBJECTIVES
To study the association between multi-morbidity percentiles, which is a measure of clinical aging, and interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α.
METHODS
Participants 50 to 95 years of age from the Mayo Clinic Study of Aging were assigned age- and sex-specific multi-morbidity percentiles using look-up tables that were reported previously (n = 1646). Percentiles were divided into quintiles for analysis. Plasma IL-6, IL-10, and TNF-α levels were measured in 1595 participants. Median inflammatory marker levels were compared across multi-morbidity quintiles using nonparametric tests.
RESULTS
People with higher multi-morbidity percentiles had significantly higher IL-6 and TNF-α levels compared with those with lower multi-morbidity percentiles. Tests for trend across five multi-morbidity quintiles were significant among women for IL-6 and among participants 70 years of age or older for IL-6 and TNF-α. IL-10 was not associated with multi-morbidity percentiles.
CONCLUSIONS
Multi-morbidity percentiles may be a useful clinical index of biological age for future studies, particularly in women and people 70 years of age and older.
目的
研究多病种百分位数（一种衡量临床衰老的指标）与白细胞介素（IL）-6、IL-10 和肿瘤坏死因子（TNF）-α之间的关联。
方法
使用先前报道的Lookup 表（n=1646），将年龄和性别特定的多疾病百分位数分配给 50 至 95 岁的 Mayo 诊所衰老研究参与者。将百分位数分为五分位数进行分析。在 1595 名参与者中测量了血浆 IL-6、IL-10 和 TNF-α 水平。使用非参数检验比较了多疾病五分位数之间的中位炎症标志物水平。
结果
与低多病种百分位数的人相比，具有较高多病种百分位数的人具有显著更高的 IL-6 和 TNF-α 水平。在女性中，IL-6 以及在 70 岁及以上的参与者中，IL-6 和 TNF-α 的五个多病种五分位数之间的趋势检验具有统计学意义。IL-10 与多病种百分位数无关。
结论
多病种百分位数可能是未来研究中生物学年龄的有用临床指标，尤其是在女性和 70 岁及以上的人群中。
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