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高剂量鼻内茶碱冲洗治疗病毒性嗅觉功能障碍的安全性：一项剂量递增研究。

Safety of High-Dose Nasal Theophylline Irrigation in the Treatment of Postviral Olfactory Dysfunction: A Dose-Escalation Study.

机构信息

Clinical Outcomes Research Office, Department of Otolaryngology-Head & Neck Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri.

Medical College of Georgia, Augusta University, Augusta.

出版信息

JAMA Otolaryngol Head Neck Surg. 2022 Sep 1;148(9):885-886. doi: 10.1001/jamaoto.2022.1574.

DOI:10.1001/jamaoto.2022.1574
PMID:35797023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9264213/
Abstract

This case series aims to determine the maximum tolerable dose of theophylline delivered via high-volume, low-pressure nasal saline irrigation for treatment of postviral olfactory dysfunction.

摘要

本病例系列旨在确定通过大体积、低压力鼻盐水冲洗给予茶碱的最大耐受剂量，以治疗病毒性嗅觉功能障碍。

相似文献

1
Safety of High-Dose Nasal Theophylline Irrigation in the Treatment of Postviral Olfactory Dysfunction: A Dose-Escalation Study.高剂量鼻内茶碱冲洗治疗病毒性嗅觉功能障碍的安全性：一项剂量递增研究。
JAMA Otolaryngol Head Neck Surg. 2022 Sep 1;148(9):885-886. doi: 10.1001/jamaoto.2022.1574.
2
Efficacy and Safety of Saline Nasal Irrigation Plus Theophylline for Treatment of COVID-19-Related Olfactory Dysfunction: The SCENT2 Phase 2 Randomized Clinical Trial.盐水鼻腔冲洗联合茶碱治疗 COVID-19 相关嗅觉功能障碍的疗效和安全性：SCENT2 阶段 2 随机临床试验。
JAMA Otolaryngol Head Neck Surg. 2022 Sep 1;148(9):830-837. doi: 10.1001/jamaoto.2022.1573.
3
Smell Changes and Efficacy of Nasal Theophylline (SCENT) irrigation: A randomized controlled trial for treatment of post-viral olfactory dysfunction.嗅味改变和鼻腔茶碱（SCENT）冲洗治疗：一项治疗病毒性嗅觉功能障碍的随机对照试验。
Am J Otolaryngol. 2022 Mar-Apr;43(2):103299. doi: 10.1016/j.amjoto.2021.103299. Epub 2021 Dec 3.
4
Regarding "Smell changes and efficacy of nasal theophylline (SCENT) irrigation: A randomized control trial for treatment of post viral olfactory dysfunction" by Lee JJ.关于李JJ的《嗅觉变化与鼻用茶碱（SCENT）冲洗的疗效：治疗病毒感染后嗅觉功能障碍的随机对照试验》
Am J Otolaryngol. 2023 Jul-Aug;44(4):103870. doi: 10.1016/j.amjoto.2023.103870. Epub 2023 Apr 5.
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Improved smell function with increased nasal mucus sonic hedgehog in hyposmic patients after treatment with oral theophylline.口服茶碱治疗后，嗅觉减退患者的鼻腔黏液中声波刺猬蛋白增加，嗅觉功能得到改善。
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Relative resistance to oral theophylline treatment in patients with hyposmia manifested by decreased secretion of nasal mucus cyclic nucleotides.嗅觉减退患者（表现为鼻粘液中环核苷酸分泌减少）对茶碱口服治疗的相对抵抗。
Am J Med Sci. 2011 Jan;341(1):17-22. doi: 10.1097/MAJ.0b013e3181f1fdc8.
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Bacterial communities in the nasal passage of postviral olfactory dysfunction patients.病毒性嗅觉功能障碍患者鼻道中的细菌群落。
Int Forum Allergy Rhinol. 2023 Oct;13(10):1962-1965. doi: 10.1002/alr.23149. Epub 2023 Mar 22.
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Nasal saline irrigation has no effect on normal olfaction: a prospective randomized trial.鼻腔盐水冲洗对嗅觉正常无影响：一项前瞻性随机试验。
Int Forum Allergy Rhinol. 2014 Jan;4(1):39-42. doi: 10.1002/alr.21235.
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On the mechanism of smell loss in patients with Type II congenital hyposmia.关于II型先天性嗅觉减退患者嗅觉丧失的机制
Am J Otolaryngol. 2016 Sep-Oct;37(5):436-41. doi: 10.1016/j.amjoto.2016.04.001. Epub 2016 Apr 20.
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Treatment of postviral olfactory loss with glucocorticoids, Ginkgo biloba, and mometasone nasal spray.用糖皮质激素、银杏叶和莫米松鼻喷雾剂治疗病毒感染后嗅觉丧失。
Arch Otolaryngol Head Neck Surg. 2009 Oct;135(10):1000-4. doi: 10.1001/archoto.2009.141.

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Traditional Chinese medicine for post-viral olfactory dysfunction: A systematic review.用于病毒感染后嗅觉功能障碍的中医药：一项系统评价
Integr Med Res. 2024 Jun;13(2):101045. doi: 10.1016/j.imr.2024.101045. Epub 2024 Apr 25.
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Treatment of COVID-19 olfactory dysfunction with olfactory training, palmitoylethanolamide with luteolin, or combined therapy: a blinded controlled multicenter randomized trial.嗅觉训练、棕榈酸乙醇酰胺和木樨草素或联合治疗 COVID-19 嗅觉功能障碍：一项盲法对照多中心随机试验。
Eur Arch Otorhinolaryngol. 2023 Nov;280(11):4949-4961. doi: 10.1007/s00405-023-08085-8. Epub 2023 Jun 28.
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Efficacy and Safety of Saline Nasal Irrigation Plus Theophylline for Treatment of COVID-19-Related Olfactory Dysfunction: The SCENT2 Phase 2 Randomized Clinical Trial.盐水鼻腔冲洗联合茶碱治疗 COVID-19 相关嗅觉功能障碍的疗效和安全性：SCENT2 阶段 2 随机临床试验。
JAMA Otolaryngol Head Neck Surg. 2022 Sep 1;148(9):830-837. doi: 10.1001/jamaoto.2022.1573.

本文引用的文献

1
Efficacy and Safety of Saline Nasal Irrigation Plus Theophylline for Treatment of COVID-19-Related Olfactory Dysfunction: The SCENT2 Phase 2 Randomized Clinical Trial.盐水鼻腔冲洗联合茶碱治疗 COVID-19 相关嗅觉功能障碍的疗效和安全性：SCENT2 阶段 2 随机临床试验。
JAMA Otolaryngol Head Neck Surg. 2022 Sep 1;148(9):830-837. doi: 10.1001/jamaoto.2022.1573.
2
Smell Changes and Efficacy of Nasal Theophylline (SCENT) irrigation: A randomized controlled trial for treatment of post-viral olfactory dysfunction.嗅味改变和鼻腔茶碱（SCENT）冲洗治疗：一项治疗病毒性嗅觉功能障碍的随机对照试验。
Am J Otolaryngol. 2022 Mar-Apr;43(2):103299. doi: 10.1016/j.amjoto.2021.103299. Epub 2021 Dec 3.
3
Growing Public Health Concern of COVID-19 Chronic Olfactory Dysfunction.日益受到关注的新型冠状病毒肺炎慢性嗅觉功能障碍
JAMA Otolaryngol Head Neck Surg. 2022 Jan 1;148(1):81-82. doi: 10.1001/jamaoto.2021.3379.
4
Interventions for the treatment of persistent post-COVID-19 olfactory dysfunction.针对新冠后持续性嗅觉功能障碍的治疗干预措施。
Cochrane Database Syst Rev. 2021 Jul 22;7(7):CD013876. doi: 10.1002/14651858.CD013876.pub2.
5
Theophylline.茶碱
Pharmaceuticals (Basel). 2010 Mar 18;3(3):725-747. doi: 10.3390/ph3030725.
6
An open-label controlled trial of theophylline for treatment of patients with hyposmia.一项关于茶碱治疗嗅觉减退患者的开放标签对照试验。
Am J Med Sci. 2009 Jun;337(6):396-406. doi: 10.1097/MAJ.0b013e3181914a97.