新型冠状病毒肺炎相关嗅觉障碍的临床研究：机构经验回顾
Clinical studies in COVID-related olfactory disorders: Review of an institutional experience.
作者信息
Tharakan Theresa, Kallogjeri Dorina, Piccirillo Jay F
机构信息
Department of Otolaryngology-Head and Neck Surgery, Clinical Outcomes Research Office, School of Medicine Washington University in St Louis St Louis Missouri USA.
出版信息
World J Otorhinolaryngol Head Neck Surg. 2024 Apr 19;10(2):129-136. doi: 10.1002/wjo2.176. eCollection 2024 Jun.
OBJECTIVE
To share a single institutional experience with clinical research on COVID-related olfactory dysfunction (OD).
DATA SOURCE/METHOD: Narrative review of published original data and ongoing clinical trials on COVID-related OD at Washington University from 2020 to 2023.
RESULTS
There were three new diagnostic-/patient-reported outcome measures developed and tested. We report five clinical trials of interventions for COVID-related olfactory disorders: combined Visual-Olfactory Training (VOLT) with patient-preferred scents versus standard olfactory training (), oral gabapentin versus placebo (), nasal theophylline irrigations versus placebo (), stellate ganglion block (single-arm), and mindfulness-based stress reduction (MBSR) versus lifestyle intervention .
CONCLUSIONS
Initial intervention trials for COVID-related OD have shown potential for improving subjective and objective olfactory outcomes. However, there remains no gold standard treatment that definitively outperforms placebo in controlled trials. Therefore, continued investigation of novel therapeutic strategies for COVID-related OD is necessary to maximize olfactory outcomes for affected patients.
目的
分享单一机构关于新冠相关嗅觉功能障碍（OD）临床研究的经验。
数据来源/方法：对华盛顿大学2020年至2023年已发表的关于新冠相关OD的原始数据和正在进行的临床试验进行叙述性综述。
结果
开发并测试了三种新的诊断/患者报告结局指标。我们报告了五项针对新冠相关嗅觉障碍的干预措施临床试验：联合视觉嗅觉训练（VOLT）与患者偏好的气味对比标准嗅觉训练（），口服加巴喷丁对比安慰剂（），鼻用茶碱冲洗对比安慰剂（），星状神经节阻滞（单臂），以及基于正念的减压疗法（MBSR）对比生活方式干预（）。
结论
针对新冠相关OD的初步干预试验已显示出改善主观和客观嗅觉结局的潜力。然而，在对照试验中，仍没有明确优于安慰剂的金标准治疗方法。因此，有必要继续研究针对新冠相关OD的新型治疗策略，以使受影响患者的嗅觉结局最大化。
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