Kv 通道辅助亚基：我们从何处出发？
Kv Channel Ancillary Subunits: Where Do We Go from Here?
机构信息
Bioelectricity Laboratory, Department of Physiology and Biophysics, School of Medicine, University of California, Irvine, California.
出版信息
Physiology (Bethesda). 2022 Sep 1;37(5):0. doi: 10.1152/physiol.00005.2022.
Abstract
Voltage-gated potassium (Kv) channels each comprise four pore-forming α-subunits that orchestrate essential duties such as voltage sensing and K selectivity and conductance. In vivo, however, Kv channels also incorporate regulatory subunits-some Kv channel specific, others more general modifiers of protein folding, trafficking, and function. Understanding all the above is essential for a complete picture of the role of Kv channels in physiology and disease.
摘要
电压门控钾 (Kv) 通道由四个形成孔的 α-亚基组成，这些亚基协调着诸如电压感应和 K 选择性以及电导率等基本功能。然而，在体内，Kv 通道还包含调节亚基——一些 Kv 通道特异性的，另一些则是蛋白质折叠、运输和功能的更通用修饰剂。了解所有这些对于理解 Kv 通道在生理和疾病中的作用的全貌至关重要。
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