Department of Biomedical Engineering and Health Systems, KTH Royal Institute of Technology, Stockholm, Sweden.
Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
Biomed Phys Eng Express. 2022 Jul 19;8(5). doi: 10.1088/2057-1976/ac7f39.
Shear wave elastography (SWE) is a promising technique for characterizing carotid plaques and assessing local arterial stiffness. The mechanical stress to which the tissue is subjected during SWE using acoustic radiation force (ARF), leading to strain at a certain strain rate, is still relatively unknown. Because SWE is increasingly used for arterial applications where the mechanical stress could potentially lead to significant consequences, it is important to understand the risks of SWE-induced strain and strain rate. The aim of this study was to investigate the safety of SWE in terms of induced arterial strain and strain rateand in a human carotid artery. SWE was performed on six porcine aortae as a model of the human carotid artery using different combinations of ARF push parameters (push voltage: 60/90 V, aperture width: f/1.0/1.5, push length: 100/150/200s) and distance to push position. The largest induced strain and strain rate were 1.46% and 54 s(90 V, f/1.0, 200s), respectively. Moreover, the SWE-induced strains and strain rates increased with increasing push voltage, aperture, push length, and decreasing distance between the region of interest and the push. In the human carotid artery, the SWE-induced maximum strain was 0.06% and the maximum strain rate was 1.58 s, compared with the maximum absolute strain and strain rate of 12.61% and 5.12 s, respectively, induced by blood pressure variations in the cardiac cycle. Our results indicate thatarterial SWE does not expose the artery to higher strain rate than normal blood pressure variations, and to strain one order of magnitude higher than normal blood pressure variations, at the push settings and distances from the region of interest used in this study.
剪切波弹性成像（SWE）是一种很有前途的技术，可用于描述颈动脉斑块并评估局部动脉僵硬度。在使用声辐射力（ARF）进行 SWE 时，组织所承受的机械应力导致在一定应变速率下产生应变，但这种机械应仍相对未知。由于 SWE 越来越多地用于动脉应用，而机械应力可能会导致重大后果，因此了解 SWE 诱导应变和应变速率的风险非常重要。本研究旨在探讨 SWE 在人颈动脉中的安全性，包括诱导的动脉应变和应变速率。使用不同的 ARF 推压参数组合（推压电压：60/90V、孔径宽度：f/1.0/1.5、推压长度：100/150/200s）和推压位置与感兴趣区之间的距离，对 6 个猪主动脉进行了 SWE 检测，作为人颈动脉的模型。最大诱导应变和应变速率分别为 1.46%和 54s（90V、f/1.0、200s）。此外，SWE 诱导的应变和应变速率随推压电压、孔径、推压长度的增加以及感兴趣区与推压区之间距离的减小而增加。在人颈动脉中，SWE 诱导的最大应变为 0.06%，最大应变速率为 1.58s，而在心动周期中血压变化引起的最大绝对应变为 12.61%，最大应变速率为 5.12s。我们的结果表明，在本研究中使用的推压设置和距离下，动脉 SWE 不会使动脉承受比正常血压变化更高的应变速率，也不会使动脉承受比正常血压变化高一个数量级的应变。
