Kibitov A A, Kasyanov E D, Nikolishin A E, Rukavishnikov G V, Malyshko L V, Popovich U O, Golimbet V E, Neznanov N G, Shmukler A B, Kibitov A O, Mazo G E
Bekhterev National Medical Research Center for Psychiatry and Neurology, St. Peterburg, Russia.
Serbsky National Medical Research Centre on Psychiatry and Addictions, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(6. Vyp. 2):56-63. doi: 10.17116/jnevro202212206256.
To study the impact of family history of mood disorders (FHMD), comprising genetic factors associated with depression, on the association between adverse childhood experience (ACE) and suicidality in depression.
This multicenter cross-sectional study included 200 in- and outpatients (64% (=128) women, mean age - (M (SD)) 36.21 (15.09) yrs.) with depression. Self-reports about FHMD and lifetime suicide attempts were obtained in clinical interview. The lifetime intensity of suicidal ideas and behavior was assessed by the Columbia-Suicide Severity Rating Scale (C-SSRS), ACE - by the Adverse Childhood Experience International Questionnaire (ACE-IQ).
FHMD did not affect the prevalence of ACE, suicide attempts and C-SSRS scores. We found that FHMD weakens the link between ACE and the risk of suicide attempt. The emotional neglect itself increased the risk of suicide attempt (=0.001, OR=4.428, CI 95% [1.797-10.911]), but reduced it in patients with FHMD (=0.03, OR=0.128, CI 95% [0.018-0.893]). GLM analysis revealed that FHMD significantly affected the association between suicidal ideas and domestic violence (=0.045) and between suicidal behavior and emotional neglect (=0.015) and abuse (=0.044).
FHMD may weaken the link between ACE and suicidality in patients with depression. Suicidality in these patients may be underlined by mechanisms not involved in the response to ACE although more studies are needed.
研究情绪障碍家族史（FHMD）（包括与抑郁症相关的遗传因素）对不良童年经历（ACE）与抑郁症自杀倾向之间关联的影响。
这项多中心横断面研究纳入了200名抑郁症门诊和住院患者（64%（=128）为女性，平均年龄 - （M（SD））36.21（15.09）岁）。在临床访谈中获取了关于FHMD和终生自杀未遂的自我报告。自杀观念和行为的终生强度通过哥伦比亚自杀严重程度评定量表（C - SSRS）进行评估，ACE通过国际不良童年经历问卷（ACE - IQ）进行评估。
FHMD不影响ACE的患病率、自杀未遂情况和C - SSRS评分。我们发现FHMD会削弱ACE与自杀未遂风险之间的联系。情感忽视本身会增加自杀未遂风险（=0.001，OR = 4.428，95%CI [1.797 - 10.911]），但在有FHMD的患者中会降低这种风险（=0.03，OR = 0.128，95%CI [0.018 - 0.893]）。广义线性模型分析显示，FHMD显著影响自杀观念与家庭暴力之间的关联（=0.045）以及自杀行为与情感忽视（=0.015）和虐待（=0.044）之间的关联。
FHMD可能会削弱抑郁症患者中ACE与自杀倾向之间的联系。这些患者的自杀倾向可能由与ACE反应无关的机制所强调，尽管还需要更多研究。
