Group of Medical Staff for Child Health at Al Islam Hospital Bandung, Indonesia.
Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
J Infect Dev Ctries. 2022 Jun 30;16(6):1113-1117. doi: 10.3855/jidc.15662.
Congenital syphilis involves any organs with various symptoms, including neurological signs. Neurosyphilis is a severe syphilis complication that can develop at any stage of illness.
A 2,520 g male infant was spontaneously born at term from an untreated syphilis mother. Physical examination revealed decreased consciousness, respiratory distress, seizure, but without neurologic abnormality sign. The serum and cerebrospinal fluid Venereal Disease Research Laboratory and Treponemal Pallidum Hemagglutination Assay TPHA tests titters were 1:16 and 1:1,280, respectively. The diagnosis at admission was respiratory failure and neonatal sepsis. The infant was mechanically ventilated and treated with early management of sepsis. Blood culture was sterile later on. Then, the infant was administered intramuscular benzathine penicillin G (50,000 units/kg/dose) for a total of three weeks. The infant's condition was improved during the treatment.
There are many challenges associated with screening and monitoring neurosyphilis in congenital syphilis. Congenital syphilis presenting as sepsis is easily misdiagnosed as bacterial sepsis.
先天性梅毒可累及任何器官，出现各种症状，包括神经学征象。神经梅毒是一种严重的梅毒并发症，可在疾病的任何阶段发生。
一名 2520 克男性婴儿，足月自然分娩于未经治疗的梅毒母亲。体格检查显示意识减退、呼吸窘迫、抽搐，但无神经异常征象。血清和脑脊液性病研究实验室和梅毒螺旋体血凝试验滴度分别为 1:16 和 1:1280。入院诊断为呼吸衰竭和新生儿败血症。婴儿接受了机械通气和早期败血症治疗。后来血培养无菌。然后，婴儿接受了肌肉注射苄星青霉素 G（50000 单位/公斤/剂量），共三周。治疗过程中婴儿病情好转。
先天性梅毒中筛查和监测神经梅毒存在诸多挑战。以败血症为表现的先天性梅毒容易误诊为细菌性败血症。
