Department of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Inorg Chem. 2022 Jul 18;61(28):10942-10949. doi: 10.1021/acs.inorgchem.2c01494. Epub 2022 Jul 7.
Colloidal quantum dots (QDs) are attractive fluorophores for bioimaging and biomedical applications because of their favorable and tunable optoelectronic properties. In this study, the native hydrophobic ligand environment of oleate-capped sphalerite CdSe/ZnS core/shell QDs was quantitatively exchanged with a set of imidazole-bearing small-molecule ligands. Inductively coupled plasma-optical emission spectroscopy and H NMR were used to identify and quantify three different ligand exchange processes: Z-type dissociation of the Zn(oleate), L-type association of the imidazole, and X-type anionic exchange of oleate with Cl, all of which contributed to the overall ligand exchange.
胶体量子点（QDs）由于其良好的可调谐光电性能，是生物成像和生物医学应用中很有吸引力的荧光团。在这项研究中，用一组含咪唑的小分子配体定量交换了油酸钠封端的闪锌矿 CdSe/ZnS 核/壳 QD 的本征疏水性配体环境。电感耦合等离子体-原子发射光谱和 1H NMR 用于鉴定和量化三种不同的配体交换过程：Zn（油酸盐）的 Z 型解离、咪唑的 L 型缔合，以及油酸盐与 Cl 的阴离子交换 X 型，所有这些都有助于整体配体交换。
