National University of Ireland, Galway, Ireland.
National University of Ireland, Galway, Ireland.
Res Dev Disabil. 2022 Sep;128:104293. doi: 10.1016/j.ridd.2022.104293. Epub 2022 Jul 4.
Angelman syndrome (AS), is a rare genetic disorder. This study investigated the relationship between parent-reported comorbid symptoms including gastrointestinal symptoms, sleep problems, internalizing symptoms, and behavior problems in children and adolescents with AS.
Parents of 98 children and adolescents with AS completed the Gastrointestinal Symptom Inventory, Children's Sleep Habits Questionnaire, Child Behavior Checklist, Social Communication Questionnaire, and the Behavior Problem Inventory-Short Form. Data were analyzed using descriptive statistics, Pearson's correlation coefficients, and hierarchical multiple regressions.
There was a high frequency of GI symptoms (99%), sleep problems (95.9%), challenging behavior (98%), internalizing symptoms (38%), and 72.4% of children and adolescents presented with ASD symptoms. Self-injurious behavior (SIB), aggressive/destructive behavior, and the frequency of stereotyped behavior positively correlated with GI symptoms and sleep problems and it was moderately negatively associated with age. Internalizing symptoms and age were positively associated with SIB. Aggression was significantly related to gender, but not the presence of ASD symptoms.
Findings highlight the relationships between comorbid conditions. They may lead to a deeper understanding of how comorbidities present in children and adolescents with Angelman Syndrome.
天使综合征（AS）是一种罕见的遗传疾病。本研究调查了父母报告的共病症状（包括胃肠道症状、睡眠问题、内化症状和行为问题）与儿童和青少年 AS 之间的关系。
98 名儿童和青少年 AS 患者的家长完成了胃肠道症状量表、儿童睡眠习惯问卷、儿童行为检查表、社会沟通问卷和行为问题清单-短表。使用描述性统计、皮尔逊相关系数和分层多元回归分析数据。
胃肠道症状（99%）、睡眠问题（95.9%）、挑战性行为（98%）、内化症状（38%）和 72.4%的儿童和青少年出现 ASD 症状的频率较高。自伤行为（SIB）、攻击/破坏性行为以及刻板行为的频率与胃肠道症状和睡眠问题呈正相关，与年龄呈中度负相关。内化症状和年龄与 SIB 呈正相关。攻击行为与性别显著相关，但与 ASD 症状的存在无关。
研究结果强调了共病之间的关系。这些结果可能有助于更深入地了解儿童和青少年天使综合征中存在的共病情况。
