Irish Centre for Autism and Neurodevelopmental Research, School of Psychology, University of Galway, Galway, Ireland.
EResearch, Queensland University of Technology, Brisbane, Australia.
Sleep Med. 2024 Nov;123:1-6. doi: 10.1016/j.sleep.2024.07.033. Epub 2024 Aug 22.
Angelman Syndrome (AS) is a neurodevelopmental disorder with severe symptoms and associated comorbidities. It is caused by the inactivity or lack of the UBE3a gene. Symptoms of the syndrome include intellectual disability and developmental delay. The current study investigated sleep disturbances (SD) in children and adolescents with AS, associations between SD and possible predictors of SD. Variables examined included age, gender, newborn and infancy history, challenging behavior, type of therapy received, genetic type of AS, and seizures. The sample included data from 109 participants with a mean age of 8.21, accessed via the Global Angelman Syndrome Registry. Chi-square tests were carried out to assess the associations between the variables and a logistical regression was carried out to assess the possible predictors of SD. Associations were found between SD and certain repetitive behaviors: slapping walls, focal hand movements, and agitation at new situations. From these associations, a regression formed a predictive model for sleep disturbances. The findings of this research demonstrated the importance of investigating the relationship between sleep disturbances and challenging behavior in children and adolescents with AS and the need for further research in this area.
安琪曼综合征（AS）是一种神经发育障碍，具有严重的症状和相关的合并症。它是由UBE3a 基因的不活跃或缺乏引起的。该综合征的症状包括智力残疾和发育迟缓。本研究调查了患有 AS 的儿童和青少年的睡眠障碍（SD），以及 SD 与 SD 可能预测因素之间的关联。检查的变量包括年龄、性别、新生儿和婴儿期的历史、挑战性行为、接受的治疗类型、AS 的遗传类型和癫痫发作。该样本包括来自全球安琪曼综合征登记处的 109 名参与者的数据，平均年龄为 8.21 岁。进行了卡方检验以评估变量之间的关联，并进行了逻辑回归以评估 SD 的可能预测因素。SD 与某些重复性行为之间存在关联：拍打墙壁、手部焦点运动和对新情况的激动。从这些关联中，回归形成了一个预测睡眠障碍的模型。这项研究的结果表明，调查患有 AS 的儿童和青少年睡眠障碍与挑战性行为之间关系的重要性，以及在这一领域进一步研究的必要性。
