Department of Nuclear Medicine, the First Affiliated Hospital of Soochow University, Suzhou, China.
Department of Nuclear Medicine, the Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical University, Suzhou, China.
Clin Imaging. 2022 Sep;89:120-127. doi: 10.1016/j.clinimag.2022.06.016. Epub 2022 Jul 2.
In the present study, we aimed to investigate the relationship between metabolic parameters of F-fluorodeoxyglucose positron emission computed tomography (F-FDG PET/CT) and the expression of programmed death ligand-1 (PD-L1), as well as the prognostic value of PD-L1, in patients with surgically resected non-small-cell lung cancer (NSCLC).
A total of 169 NSCLC patients who received preoperative F-FDG PET were retrospectively enrolled in the present study. The correlation between PD-L1 and patient characteristics was evaluated. Based on the expression of PD-L1 and metabolic parameters, patients were classified into low-, medium-, or high-risk groups.
The maximum standardized uptake value (SUV) and total lesion glycolysis (TLG) were significantly higher in NSCLC patients with high PD-L1 expression compared with the low expression group (P < 0.001 for all). Multivariate analysis revealed that pleural invasion (P < 0.001) and SUV (P < 0.001) were independent predictors of PD-L1 expression. Survival analysis showed that tumor stage (P = 0.004) and pleural invasion (P = 0.007) were independent prognostic indicators of progression-free survival (PFS). Tumor stage (P = 0.001), TLG (P = 0.039), and PD-L1 expression (P = 0.001) were independent prognostic indicators of overall survival (OS). Patients of the high-risk group with high PD-L1 expression and high TLG had a poor prognosis compared with the low-risk group (P < 0.05) and medium-risk group (P < 0.05).
In NSCLC patients, the SUV of F-FDG PET/CT was a predictor of PD-L1 expression. The expression of PD-L1 and TLG were independent prognostic factors of OS. The risk stratification standard based on the PD-L1 expression and TLG provided valuable insights into the development of personalized treatment and follow-up.
ChiCTR2100051554.
本研究旨在探讨氟-18 氟代脱氧葡萄糖正电子发射断层扫描（F-FDG PET/CT）代谢参数与程序性死亡配体-1（PD-L1）表达的关系，以及 PD-L1 对接受手术切除的非小细胞肺癌（NSCLC）患者的预后价值。
回顾性纳入了 169 例接受术前 F-FDG PET 的 NSCLC 患者。评估了 PD-L1 与患者特征之间的相关性。根据 PD-L1 和代谢参数的表达，患者被分为低、中、高风险组。
高 PD-L1 表达组 NSCLC 患者的最大标准摄取值（SUV）和总病灶糖酵解（TLG）明显高于低表达组（均 P<0.001）。多因素分析显示，胸膜侵犯（P<0.001）和 SUV（P<0.001）是 PD-L1 表达的独立预测因素。生存分析显示，肿瘤分期（P=0.004）和胸膜侵犯（P=0.007）是无进展生存期（PFS）的独立预后指标。肿瘤分期（P=0.001）、TLG（P=0.039）和 PD-L1 表达（P=0.001）是总生存期（OS）的独立预后因素。高 PD-L1 表达和高 TLG 的高危组患者的预后明显差于低危组（P<0.05）和中危组（P<0.05）。
在 NSCLC 患者中，F-FDG PET/CT 的 SUV 是 PD-L1 表达的预测因素。PD-L1 表达和 TLG 是 OS 的独立预后因素。基于 PD-L1 表达和 TLG 的风险分层标准为制定个性化治疗和随访方案提供了有价值的信息。
ChiCTR2100051554。
