利用 IgG Fc 糖基化获得临床获益。
Harnessing IgG Fc glycosylation for clinical benefit.
机构信息
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, CA, USA; Program in Immunology, Stanford University School of Medicine, Stanford, CA, USA.
出版信息
Curr Opin Immunol. 2022 Aug;77:102231. doi: 10.1016/j.coi.2022.102231. Epub 2022 Jul 4.
Abstract
The effector activity of IgG antibodies is regulated at several levels, including IgG subclass, modifications of the Fc glycan, and the distribution of Type I and II Fcγ receptors (FcγR) on effector cells. Here, we explore how Fc glycosylation, particularly sialylation and fucosylation, tunes cellular responses to immune complexes. We review the current understanding of the pathways and mechanisms underlying this biology, address FcγR in antigen presentation, and discuss aspects of the clinical understanding of Fc glycans in therapies and disease.
摘要
IgG 抗体的效应器活性在多个水平受到调节，包括 IgG 亚类、Fc 聚糖的修饰以及效应细胞上的 I 型和 II 型 Fcγ 受体（FcγR）的分布。在这里，我们探讨了 Fc 糖基化（特别是唾液酸化和岩藻糖化）如何调节细胞对免疫复合物的反应。我们回顾了目前对这一生物学的途径和机制的理解，讨论了 FcγR 在抗原呈递中的作用，并讨论了 Fc 聚糖在治疗和疾病中的临床理解的各个方面。
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