肿瘤微环境中的中性粒细胞及其被间充质基质细胞调节的功能。
Neutrophils in the tumor microenvironment and their functional modulation by mesenchymal stromal cells.
机构信息
The Third Affiliated Hospital of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine of Soochow University, Suzhou, Jiangsu, China; Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Cancer Center, Department of Breast Surgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
Key Laboratory of Tumor Microenvironment and Immune Therapy of Zhejiang Province, Cancer Center, Department of Breast Surgery, The Second Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
出版信息
Cell Immunol. 2022 Sep;379:104576. doi: 10.1016/j.cellimm.2022.104576. Epub 2022 Jul 1.
Neutrophils are the most predominant cell population in the innate immune system. The role of neutrophils in the initiation, development and metastasis of tumor has been actively studied in recent years. In cancer, neutrophils exert both pro- and anti-cancer effects, and their phenotype and function are affected by the tumor microenvironment (TME). This review aims to summarize the role of neutrophils in tumorigenesis with emphasis on their interaction with mesenchymal stromal cells (MSCs).
中性粒细胞是先天免疫系统中最主要的细胞群体。近年来，中性粒细胞在肿瘤的发生、发展和转移中的作用受到了积极的研究。在癌症中，中性粒细胞发挥着促癌和抗癌作用，其表型和功能受肿瘤微环境（TME）的影响。本文旨在总结中性粒细胞在肿瘤发生中的作用，重点讨论其与间充质基质细胞（MSCs）的相互作用。
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