Li Zhihui, Li Hua, Wang Peng, Xie Wei, Shao Guo, Zhu Hongwei
The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, China.
Inner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Baotou, Inner Mongolia, China.
Sci Rep. 2025 Jul 22;15(1):26545. doi: 10.1038/s41598-025-12094-4.
Inflammation has been recognized as a pivotal factor in the pathophysiology of diabetes. The aggregate index of systemic inflammation (AISI) has recently been proposed as a novel biomarker for evaluating inflammatory status and predicting clinical outcomes. However, evidence on the association between AISI and mortality in diabetic patients remains limited. To address this knowledge gap, we aimed to investigate the association between AISI and mortality risk from cardio-cerebrovascular disease (CCD) and malignant neoplasms in diabetic patients. We analyzed data from the National Health and Nutrition Examination Survey (NHANES, 2001-2018). Multivariable-adjusted Cox models revealed strong associations between elevated AISI levels and CCD mortality (HR 1.18, 95% CI 1.11-1.26) as well as malignant neoplasm mortality (HR 1.20, 95% CI 1.10-1.30). Kaplan-Meier analysis showed that higher AISI was associated with lower survival in diabetic patients for both CCD and malignant neoplasms. Restricted cubic spline (RCS) analysis demonstrated an increased risk of mortality from CCD and malignant neoplasms in diabetic patients with elevated AISI levels. Subgroup and sensitivity analyses confirmed the robustness of these findings. In adults with diabetes, elevated AISI levels are strongly associated with an increased risk of mortality from CCD and malignant neoplasms.
炎症已被公认为糖尿病病理生理学中的一个关键因素。全身炎症综合指数（AISI）最近被提议作为一种评估炎症状态和预测临床结局的新型生物标志物。然而，关于AISI与糖尿病患者死亡率之间关联的证据仍然有限。为了填补这一知识空白，我们旨在研究AISI与糖尿病患者心血管疾病（CCD）和恶性肿瘤死亡风险之间的关联。我们分析了国家健康和营养检查调查（NHANES，2001 - 2018年）的数据。多变量调整后的Cox模型显示，AISI水平升高与CCD死亡率（风险比1.18，95%置信区间1.11 - 1.26）以及恶性肿瘤死亡率（风险比1.20，95%置信区间1.10 - 1.30）之间存在强关联。Kaplan - Meier分析表明，较高的AISI与糖尿病患者CCD和恶性肿瘤的较低生存率相关。受限立方样条（RCS）分析表明，AISI水平升高的糖尿病患者因CCD和恶性肿瘤导致的死亡风险增加。亚组分析和敏感性分析证实了这些发现的稳健性。在成年糖尿病患者中，AISI水平升高与CCD和恶性肿瘤死亡风险增加密切相关。
