College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen 518118, P. R. China.
College of New Materials and New Energies, Shenzhen Technology University, Shenzhen 518118, P. R. China.
Nanoscale. 2022 Aug 4;14(30):10750-10760. doi: 10.1039/d2nr02908a.
Stimulus-responsive ternary chalcogenide nanomaterials are regarded as promising 'all-in-one' nanotheranostics agents on account of their tunable band structures and multi-metal intrinsic properties. Herein, ultrasmall AgBiSe nanodots are prepared by a simple thermal injection method. It shows a narrow band gap of 0.91 eV and high absorption coefficient in the NIR-II biowindow, resulting in excellent photothermal performance. Under the irradiation of a 1064 nm laser, AgBiSe can induce the overexpression of intracellular heat shock protein (Hsp70) and cell apoptosis to inhibit the growth of tumor cells. The strong signal from CT/thermal imaging also provides guidance for tumor diagnosis. Importantly, AgBiSe can be rapidly excreted from the body, thus avoiding long term toxicity. This study presents the first biomedical application of AgBiSe nanodots in cancer treatment and extends the development of ternary chalcogenide-based semiconductor nanomedicine.
基于可调带隙结构和多金属固有特性，响应型三元碲化物纳米材料被视为很有前途的“一体化”纳米诊疗试剂。在此，通过简单的热注射法制备了超小的 AgBiSe 纳米点。它在近红外二区（NIR-II）生物窗口显示出 0.91eV 的窄带隙和高吸收系数，从而具有优异的光热性能。在 1064nm 激光照射下，AgBiSe 能够诱导细胞内热休克蛋白（Hsp70）的过度表达和细胞凋亡，从而抑制肿瘤细胞的生长。CT/热成像的强信号也为肿瘤诊断提供了指导。重要的是，AgBiSe 可以从体内快速排出，从而避免长期毒性。本研究首次将 AgBiSe 纳米点应用于癌症治疗的生物医学领域，并拓展了基于三元碲化物的半导体纳米医学的发展。
