用于体内计算机断层成像和光热治疗的可清除肾脏的 Ag 纳米点。
Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy.
机构信息
Beijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optoelectronics, Beijing Institute of Technology , Beijing 100081, China.
Department of Interventional Ultrasound, Chinese PLA General Hospital , Beijing 100853, China.
出版信息
ACS Appl Mater Interfaces. 2017 Feb 22;9(7):5900-5906. doi: 10.1021/acsami.6b16133. Epub 2017 Feb 9.
Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.
白蛋白稳定的银纳米点（ANDs）通过一步生物矿化法制备。这些高度结晶的纳米点具有超小的尺寸（约 5.8nm）和强大的 X 射线衰减能力（每 mM Ag 为 5.7313 HU）。在体内 X 射线计算机断层扫描（CT）成像应用后，未标记的 ANDs 可通过尿液直接从体内排出。ANDs 可用作 CT 成像剂和有效的光热治疗剂。用光热治疗 ANDs 后，肿瘤生长抑制率达到 90.2%。ANDs 是用于体内 CT 成像和可清除的近红外触发治疗剂的有前途的工具。
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