Beijing Engineering Research Center of Mixed Reality and Advanced Display, School of Optoelectronics, Beijing Institute of Technology , Beijing 100081, China.
Department of Interventional Ultrasound, Chinese PLA General Hospital , Beijing 100853, China.
ACS Appl Mater Interfaces. 2017 Feb 22;9(7):5900-5906. doi: 10.1021/acsami.6b16133. Epub 2017 Feb 9.
Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.
白蛋白稳定的银纳米点（ANDs）通过一步生物矿化法制备。这些高度结晶的纳米点具有超小的尺寸（约 5.8nm）和强大的 X 射线衰减能力（每 mM Ag 为 5.7313 HU）。在体内 X 射线计算机断层扫描（CT）成像应用后，未标记的 ANDs 可通过尿液直接从体内排出。ANDs 可用作 CT 成像剂和有效的光热治疗剂。用光热治疗 ANDs 后，肿瘤生长抑制率达到 90.2%。ANDs 是用于体内 CT 成像和可清除的近红外触发治疗剂的有前途的工具。
