National Engineering Research Center for Nanomedicine, and College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
Biomaterials. 2018 Feb;154:248-260. doi: 10.1016/j.biomaterials.2017.10.030. Epub 2017 Oct 20.
Photoactive noble metal nanoparticles are of increasing importance toward personalized cancer therapy in the field of precision nanomedicine. A critical challenge remains in the exploration of clinically potential noble metal nanoparticles for highly efficient cancer theranostics. Here, we introduce albumin-coordinated assembly of clearable Pt nanodots (Pt-NDs) with monodisperse nanostructure as high-performance theranostic agents for imaging-guided photothermal tumor ablation. We precisely manipulate the reduction and growth of tetravalent Pt ions into ultrasmall nanodots through albumin-directed growth kinetics, thereby leading to the synthesis of monodisperse 6.7 nm Pt-NDs with albumin molecules as the corona. Pt-NDs exhibit the surface plasmon resonance at 225 nm with enhanced near-infrared (NIR) absorbance, ideal resistance to photo-bleaching, distinct photoacoustic and X-ray signals, as well as remarkable photothermal effect through non-radiative relaxation under NIR light irradiation. In particular, Pt-NDs possess preferable tumor accumulation, and effective in vivo excretory capability. Thus, these nanodots promote preferable in vivo microscopic photoacoustics and spatially anatomic CT imaging with enhanced contrast, as well as potent hyperthermia-mediated tumor ablation. These findings represent a facile and general approach to fabricate high-performance noble metal nanostructures with clinical potential for cancer theranostics.
光活性贵金属纳米粒子在精准纳米医学领域的个性化癌症治疗中变得越来越重要。在探索临床潜在的贵金属纳米粒子以实现高效癌症治疗方面仍然存在一个关键挑战。在这里，我们介绍了可清除的白蛋白协调组装的 Pt 纳米点（Pt-NDs），具有单分散纳米结构，可用作用于成像引导光热肿瘤消融的高性能治疗剂。我们通过白蛋白定向生长动力学精确地控制四价 Pt 离子的还原和生长，从而合成了具有白蛋白作为冠的单分散 6.7nmPt-NDs。Pt-NDs 在 225nm 处表现出表面等离子体共振，具有增强的近红外（NIR）吸收，理想的抗光漂白性，明显的光声和 X 射线信号，以及通过 NIR 光照射下的非辐射弛豫产生的显著光热效应。特别是，Pt-NDs 具有更好的肿瘤积累和有效的体内排泄能力。因此，这些纳米点促进了更好的体内微观光声和空间解剖 CT 成像，具有增强的对比度，以及有效的高热介导的肿瘤消融。这些发现代表了一种简单而通用的方法，可以制备具有临床潜力的用于癌症治疗的高性能贵金属纳米结构。
