负重运动可逆转运动不足引起的负净钙平衡。

Hypokinesia-induced negative net calcium balance reversed by weight-bearing exercise.

作者信息

Lutz J, Chen F, Kasper C E

出版信息

Aviat Space Environ Med. 1987 Apr;58(4):308-14.

Abstract

Negative calcium balance and bone loss occurring with immobilization and hypokinesia have been attributed to a lack of weight bearing on bones. The effects of weight-bearing exercise for promotion of calcium balance after hypokinesia were examined. Rats were randomly assigned to either hypokinetic suspension for 28 d or to a control sedentary group, free to move about their cages at will. After 28 d, the rats in each group were randomly subdivided to either post-hypokinetic forced running (HR), post-hypokinetic sedentary (HS), control forced running (CR), or control sedentary (CS) groups. Net calcium balance was then determined for 25 consecutive days. Net calcium balance of HR was negative for the first 5-d period of recovery and then became positive; that of HS was negative for 25 d; that of CR and CS remained essentially positive. Net calcium absorption paralleled net calcium balance. Forced running was effective in reestablishment of positive net calcium balance after 28 d of decreased weight bearing.

摘要

制动和运动不足时出现的负钙平衡和骨质流失被认为是由于骨骼缺乏负重所致。研究了负重运动对运动不足后促进钙平衡的影响。将大鼠随机分为两组，一组进行28天的运动不足悬吊，另一组为对照久坐组，可在笼中自由活动。28天后，每组大鼠再随机细分为运动不足后强迫跑步（HR）组、运动不足后久坐（HS）组、对照强迫跑步（CR）组或对照久坐（CS）组。然后连续25天测定净钙平衡。HR组在恢复的前5天净钙平衡为负，之后转为正；HS组25天净钙平衡均为负；CR组和CS组基本保持为正。净钙吸收与净钙平衡平行。在负重减少28天后，强迫跑步有效地重建了正的净钙平衡。