From the Department of Radiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
From the Department of Radiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China
AJNR Am J Neuroradiol. 2022 Jul;43(7):1054-1059. doi: 10.3174/ajnr.A7556.
Primary intracranial pure yolk sac tumor is very rare. Our aim was to summarize the characteristics of primary intracranial pure yolk sac tumors from the clinical and imaging aspects in a retrospective study.
We studied 5 patients with primary intracranial pure yolk sac tumors in Guangzhou Women and Children's Medical Center from January 2015 to June 2021. A comprehensive literature search was performed on the electronic database of the China National Knowledge Infrastructure (1990 to June 2021). Clinical data based on age, sex, treatment, CT, and MR imaging findings were collected and analyzed.
A total of 25 patients were included in the study, 21 boys and 4 girls. Twenty-one patients underwent plain MR imaging and an enhanced examination, 9 patients underwent DWI, and 12 patients underwent plain CT and/or an enhanced examination. The tumors were posterior fossa in 9 cases and supratentorial in 16 cases. All tumors showed marked enhancement after enhanced scanning by MR imaging or CT. The signal on DWI was similar to that of the cerebral cortex, and the ADC map was similar to or slightly higher than that of the cerebral cortex. Among the cases, 13 were followed up from 2 months to 5 years. There was no recurrence or metastasis in 9 patients with postoperative chemotherapy or chemoradiotherapy followed up for 1.5-5 years. Four patients died 2 months to 1.5 years after only an operation, or chemoradiotherapy but no operation.
There are some relatively specific imaging findings of primary intracranial yolk sac tumors that could assist in their diagnosis. Surgery combined with radiation therapy and/or chemotherapy can achieve a better prognosis.
原发性颅内纯卵黄囊瘤非常罕见。本研究旨在回顾性分析原发性颅内纯卵黄囊瘤的临床和影像学特征。
我们研究了 2015 年 1 月至 2021 年 6 月在广州妇女儿童医疗中心的 5 例原发性颅内纯卵黄囊瘤患者。我们在中国知网（1990 年至 2021 年 6 月）电子数据库上进行了全面的文献检索。收集并分析了基于年龄、性别、治疗、CT 和 MRI 成像结果的临床数据。
共纳入 25 例患者，男 21 例，女 4 例。21 例行平扫及增强 MRI 检查，9 例行 DWI 检查，12 例行平扫 CT 及/或增强检查。肿瘤位于后颅窝 9 例，幕上 16 例。所有肿瘤在 MR 成像或 CT 增强扫描后均表现为明显强化。DWI 上信号与皮质相似，ADC 图与皮质相似或稍高。其中，13 例获得随访，随访时间为 2 个月至 5 年。术后化疗或放化疗的 9 例患者随访 1.5-5 年，未见复发或转移。仅行手术或手术加放化疗但未行化疗的 4 例患者分别于术后 2 个月至 1.5 年内死亡。
原发性颅内卵黄囊瘤具有一些相对特异的影像学表现，有助于诊断。手术联合放化疗可获得较好的预后。
