INRAE, UR1268 BIA, F-44316 Nantes, France.
Carbohydr Polym. 2022 Oct 1;293:119700. doi: 10.1016/j.carbpol.2022.119700. Epub 2022 Jun 14.
The layer-by-layer technique (LbL) using polysaccharides is receiving increasing interest as the preparation of nano- and micro- multilayer objects composed by natural materials is a promising alternative for actual systems. The use of bacterial polysaccharides and more particularly, dextrans and dextran derivatives, in LbL assemblies allows the simple formation of biodegradable and biocompatible multilayers with engineered functionalities. The choice of dextrans and derivatives along with the assembly conditions can indeed control internal structure and physical, chemical and biological properties. In this review, we describe the use of dextrans and dextran derivatives into multilayers presented in literature, from the method and principles to the key parameters that need to be considered in their formations. We present their valorisation into nanoobjects with specific and stimuli-responsive properties that are mainly exploited for biomedical applications as drug delivery devices.
使用多糖的层层技术（LbL）作为制备由天然材料组成的纳米和微多层物体的方法越来越受到关注，因为这是实际系统的一种有前途的替代方法。在 LbL 组装中使用细菌多糖，特别是葡聚糖和葡聚糖衍生物，可以简单地形成具有工程功能的生物可降解和生物相容性的多层结构。葡聚糖和衍生物的选择以及组装条件确实可以控制内部结构以及物理、化学和生物学性质。在这篇综述中，我们描述了文献中报道的葡聚糖和葡聚糖衍生物在多层结构中的应用，从方法和原理到形成过程中需要考虑的关键参数。我们将其转化为具有特定和刺激响应特性的纳米物体，主要用于药物输送装置等生物医学应用。
