Fishman J H, Fishman J
Biochem Biophys Res Commun. 1987 Apr 14;144(1):505-11. doi: 10.1016/s0006-291x(87)80538-7.
Copper is an essential element in living organisms and it appears to be involved in estrogen action. This study bears on the manner in which the metal may be linked to the mechanism of this action. Divalent copper was found to induce at 37 degrees C a several fold increase in estradiol binding to the receptors in rat uterine cytosols. An endogenous substance present in the uterine cytosol and separated from it by fractionation on a hydroxylapatite column was found to function as a potent inhibitor of the copper effect. This substance has been found so far also in human breast tissue and in some human breast tumors.
铜是生物体内的一种必需元素，它似乎参与雌激素作用。本研究涉及该金属与这种作用机制的关联方式。发现二价铜在37摄氏度时可使雌二醇与大鼠子宫胞质溶胶中受体的结合增加数倍。在子宫胞质溶胶中存在并通过羟基磷灰石柱分级分离出来的一种内源性物质被发现可作为铜效应的有效抑制剂。迄今为止，在人类乳腺组织和一些人类乳腺肿瘤中也发现了这种物质。
