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Mechanism of oxidation of 1-methyl-4-phenyl-2,3-dihydropyridinium (MPDP+).

作者信息

Korytowski W, Felix C C, Kalyanaraman B

出版信息

Biochem Biophys Res Commun. 1987 Apr 29;144(2):692-8. doi: 10.1016/s0006-291x(87)80020-7.

DOI:10.1016/s0006-291x(87)80020-7
PMID:3579936
Abstract

Oxidase electrode measurements have shown that the neurotoxin metabolite 1-methyl-4-phenyl-2,3-dihydropyridinium autoxidizes to hydrogen peroxide and 1-methyl-4-phenylpyridinium in a reaction promoted by iron chelates. The mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity is discussed in the light of these findings.

摘要

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