Department of Pulmonary Nodule Center, The Second People's Hospital of Kunshan, Suzhou City 215300, China.
Comput Math Methods Med. 2022 Jun 28;2022:2813142. doi: 10.1155/2022/2813142. eCollection 2022.
Chemotherapy is a commonly used strategy for advanced lung cancer patients. However, its clinical application is restrained due to its toxicity and drug resistance. Ginsenoside Rg3 (Rg3) has a strong anticancer influence on colon cancer, breast cancer, lung cancer, and other malignant tumors. However, it is still unclear whether Rg3 can cooperate with 5-FU to inhibit the tumor growth and angiogenesis of lung adenocarcinoma (LUAD). This study examined the combined treatment of Rg3 and 5-FU in LUAD. It was revealed that the combined treatment could notably enhance the suppression on proliferative, invasive, and migratory abilities and angiogenesis in LUAD cells A549 and SPC-A-1. On the other hand, we also discovered that Rg3 or 5-FU could suppress the activity of the NF-B signaling pathway and downregulate VEGFA expression in LUAD cells. Collectively, this study suggested that Rg3 combined chemotherapy may perform a more powerful drug efficiency in LUAD cells.
化疗是晚期肺癌患者常用的治疗策略。然而，由于其毒性和耐药性，其临床应用受到限制。人参皂苷 Rg3（Rg3）对结肠癌、乳腺癌、肺癌等恶性肿瘤具有较强的抗癌作用。然而，人参皂苷 Rg3 是否能与 5-FU 联合抑制肺腺癌（LUAD）的肿瘤生长和血管生成仍不清楚。本研究探讨了 Rg3 和 5-FU 联合治疗 LUAD 的情况。结果表明，联合治疗能显著增强对 LUAD 细胞 A549 和 SPC-A-1 的增殖、侵袭和迁移能力以及血管生成的抑制作用。另一方面，我们还发现 Rg3 或 5-FU 可抑制 LUAD 细胞中 NF-B 信号通路的活性并下调 VEGFA 的表达。综上所述，本研究提示 Rg3 联合化疗可能在 LUAD 细胞中具有更强的药物疗效。
