Zhang Yuanda, Bi Jing, Wang Meiying, Deng Hongyu, Yang Wenli
Yuanda Zhang, Department of Nutrition, Baoding Key Laboratory of Clinical Research on Children's Respiratory and Digestive Diseases, Baoding, Hebei, 071000, P.R. China.
Jing Bi, Department of Infectious Diseases, Baoding Laboratory for Accurate Diagnosis and Treatment of Pediatric Infectious Diseases, Baoding, Hebei, 071000, P.R. China.
Pak J Med Sci. 2022 May-Jun;38(5):1188-1192. doi: 10.12669/pjms.38.5.5175.
To investigate the correlation between Helicobacter pylori (Hp) infection and Iron deficiency (ID) in children.
This cross-sectional study was conducted at Baoding Children's Hospital from January 2018 to December 2019. A total of one thousand children who came to our hospital for physical examination and met the inclusion criteria were continuously included in this study. All the children were given questionnaires (personal and family social and economic status), a stool Hp antigen test and/or a 13C-urea breath test, as well as measurements of hemoglobin (Hb), mean red blood cell volume (MCV), red blood cell distribution width (RDW), mean corpuscular hemoglobin concentration (MCHC), serum ferritin (SF), serum iron (SI), and total iron binding capacity (TIBC). Children who tested positive for Hp were divided into the Hp group and children who tested negative for Hp were divided into the control group. ID or IDA was diagnosed based on the child's blood test results.
A total of 902 children met the inclusion criteria, including 194 (21.5%) in the Hp group and 708 (78.5%) in the control group. The incidence of ID and IDA in Hp group was higher than that in control group (2=9.112, 2=4.478; All P < 0.05); The levels of MCV, SI, SF and Hb in Hp group were lower than those in control group (t=5.288; T = 3.864; T = 6.751; T =11.841, all P < 0.05), TIBC level was higher than that of control group (T =7.630, P < 0.05); The levels of MCHC and RDW in THE Hp group were not statistically significant compared with the control group. Logistic regression showed that Hp infection was not a combined risk factor for ID. Older age, higher educational background of the mother, living in the city, and higher family income were the combined protective factors to prevent the occurrence of ID in children.
Hp infection is not a combined risk factor for the development of ID in children. The influence of family social and economic factors should be taken into consideration when analyzing the correlation between Hp infection and ID.
探讨儿童幽门螺杆菌（Hp）感染与缺铁（ID）之间的相关性。
本横断面研究于2018年1月至2019年12月在保定市儿童医院进行。共有1000名来我院体检且符合纳入标准的儿童连续纳入本研究。所有儿童均接受问卷调查（个人及家庭社会经济状况）、粪便Hp抗原检测和/或13C尿素呼气试验，以及血红蛋白（Hb）、平均红细胞体积（MCV）、红细胞分布宽度（RDW）、平均红细胞血红蛋白浓度（MCHC）、血清铁蛋白（SF）、血清铁（SI）和总铁结合力（TIBC）的检测。Hp检测呈阳性的儿童分为Hp组，Hp检测呈阴性的儿童分为对照组。根据儿童血液检测结果诊断ID或缺铁性贫血（IDA）。
共有902名儿童符合纳入标准，其中Hp组194名（21.5%），对照组708名（78.5%）。Hp组ID和IDA的发生率高于对照组（χ²=9.112，χ²=4.478；P均<0.05）；Hp组MCV、SI、SF和Hb水平低于对照组（t=5.288；t = 3.864；t = 6.751；t =11.841，P均<0.05），TIBC水平高于对照组（t =7.630，P < 0.05）；Hp组MCHC和RDW水平与对照组相比差异无统计学意义。Logistic回归显示，Hp感染不是ID的合并危险因素。年龄较大、母亲教育背景较高、居住在城市以及家庭收入较高是预防儿童发生ID的合并保护因素。
Hp感染不是儿童发生ID的合并危险因素。在分析Hp感染与ID的相关性时，应考虑家庭社会经济因素的影响。
