Yuan Wei, Tan Tao, Liu Ying, Du Yingjie, Zhang Shengjuan, Wang Junrong
Oral and Maxillofacial Surgery, Hebei Eye Hospital, Xingtai, Hebei 054000, China.
Evid Based Complement Alternat Med. 2022 Jun 28;2022:9910049. doi: 10.1155/2022/9910049. eCollection 2022.
To investigate the relationship between vascular endothelial growth factor-C (VEGF-C) and tumor-associated macrophages in oral cancer (TAMs) with lymph node metastasis.
From January 2018 to January 2022, 155 cases of oral cancer tissues and 165 cases of normal mucosal tissues were collected from oral surgical resection tissues or biopsy specimens in Hebei Eye Hospital. Oral cancer tissues were observed. The control group had normal mucosal tissues. The clinical and immune parameters were observed and the treatment of oral cancer is also briefly discussed.
The number of TAMs and the expression of VEGF-C in oral cancer tissues were significantly higher than those in normal tissues ( < 0.05). The lymphatic vessel density, the number of TAMs, and the expression of VEGF-C in the metastatic group were higher than in nonmetastatic group, and the lymphatic vessel density, the number of TAMs, and the expression of VEGF-C in the paracancerous tissues were higher than central tumor tissue in the metastatic group ( < 0.05). Univariate analysis showed that the number of TAMs was related to the histological stage and the pathological type of oral cancer ( > 0.05). The expression of VEGF-C was associated with the histological stage of oral cancer ( < 0.05). Compared with the immune function after different treatments, the contents of CD4+ in both groups was higher than before, and the combined treatment group was increased more than single treatment group ( < 0.05). The contents of CD3+ and CD8+ in the two groups were lower than before, and the combined treatment group was decreased higher than combined treatment group ( < 0.05).
The number of TAMs and the expression of VEGF-C in oral cancer tissues are higher than normal tissues. The number of TAMs and the expression of VEGF-C are higher in patients with lymph node metastasis. TAMs and VEGF-C may play an important role in lymph node metastasis of oral cancer. Integrated traditional Chinese and Western medicine can improve the immune function of patients with oral cancer and may improve the therapeutic efficacy.
探讨血管内皮生长因子-C（VEGF-C）与口腔癌伴淋巴结转移中肿瘤相关巨噬细胞（TAMs）之间的关系。
收集2018年1月至2022年1月河北眼科医院口腔外科手术切除组织或活检标本中的155例口腔癌组织和165例正常黏膜组织。观察口腔癌组织。对照组为正常黏膜组织。观察临床和免疫参数，并简要讨论口腔癌的治疗。
口腔癌组织中TAMs数量和VEGF-C表达均显著高于正常组织（P<0.05）。转移组的淋巴管密度、TAMs数量和VEGF-C表达高于非转移组，转移组癌旁组织的淋巴管密度、TAMs数量和VEGF-C表达高于中央肿瘤组织（P<0.05）。单因素分析显示，TAMs数量与口腔癌的组织学分期和病理类型相关（P>0.05）。VEGF-C表达与口腔癌的组织学分期相关（P<0.05）。与不同治疗后的免疫功能相比，两组CD4+含量均高于治疗前，联合治疗组升高幅度大于单一治疗组（P<0.05）。两组CD3+和CD8+含量均低于治疗前，联合治疗组降低幅度高于单一治疗组（P<0.05）。
口腔癌组织中TAMs数量和VEGF-C表达高于正常组织。有淋巴结转移患者的TAMs数量和VEGF-C表达更高。TAMs和VEGF-C可能在口腔癌淋巴结转移中起重要作用。中西医结合可提高口腔癌患者的免疫功能，可能提高治疗效果。
