Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China.
Guangdong Province Key Laboratory of Stomatology, Guangzhou, Guangdong, China.
Adv Exp Med Biol. 2020;1296:49-78. doi: 10.1007/978-3-030-59038-3_4.
Cancer cells interact with and remodel the surrounding microenvironment. An increasing number of studies focus on tongue tumor microenvironment (TME) to find novel approaches to investigate tongue cancer, indicating that tongue tumor microenvironment is recognized as a critical element for tongue tumor development and metastasis and as a potential therapeutic target. In this paper, we review the extrinsic features of the tongue tumor microenvironment, including its various components, and the intrinsic characteristics of TME, including heterogeneity, cell death, and metastatic potential. We also report on the cross talk between these intrinsic and extrinsic components. We believe that the exploration of the tongue tumor microenvironment can provide guidance for the treatments and improve the overall survival and quality of patients' lives.
癌细胞与周围的微环境相互作用并重塑微环境。越来越多的研究关注舌肿瘤微环境（TME），以寻找新的方法来研究舌癌，这表明舌肿瘤微环境被认为是舌肿瘤发展和转移的关键因素，也是潜在的治疗靶点。在本文中，我们综述了舌肿瘤微环境的外在特征，包括其各种成分，以及 TME 的内在特征，包括异质性、细胞死亡和转移潜能。我们还报告了这些内在和外在成分之间的相互作用。我们相信，对舌肿瘤微环境的探索可以为治疗提供指导，并提高患者的总体生存率和生活质量。
