Lamont A S, Roberts M S, Holdsworth D G, Atherton A, Shepherd J J
Anaesth Intensive Care. 1986 Nov;14(4):360-4. doi: 10.1177/0310057X8601400406.
Recently, a family tree with a predisposition for the gene of multiple endocrine neoplasia Type 1 has been identified in Tasmania. As the surgical identification and localisation of parathyroid adenomas is facilitated by the administration of methylene blue, an opportunity has presented to measure the plasma concentration of methylene blue and methaemoglobin production. The study was undertaken to establish whether significant methaemoglobin concentrations were generated during the infusion and whether these concentrations could be related to the corresponding methylene blue concentrations. Mean peak methylene blue concentrations of 3.72 micrograms l-1, mean percentage methaemoglobin of 10.0 and a PaO2 within acceptable clinical ranges were found. No apparent relationship between methylene blue concentration and methaemoglobin production was found.
最近，在塔斯马尼亚发现了一个有多发性内分泌腺瘤1型基因易感性的家族谱系。由于亚甲蓝的使用有助于甲状旁腺腺瘤的手术识别和定位，因此有机会测量亚甲蓝的血浆浓度和高铁血红蛋白的产生。本研究旨在确定在输注过程中是否会产生显著的高铁血红蛋白浓度，以及这些浓度是否与相应的亚甲蓝浓度有关。结果发现，亚甲蓝的平均峰值浓度为3.72微克/升，高铁血红蛋白的平均百分比为10.0，动脉血氧分压在可接受的临床范围内。未发现亚甲蓝浓度与高铁血红蛋白产生之间存在明显关系。
