亚甲蓝在体内产生和还原高铁血红蛋白以及亚甲蓝与亚硝酸钠的相互作用。
Methaemoglobin production and reduction by methylene blue and the interaction of methylene blue with sodium nitrite in vivo.
作者信息
Marrs T C, Bright J E, Inns R H
机构信息
CDE, Salisbury, Wiltshire, UK.
出版信息
Hum Toxicol. 1989 Sep;8(5):359-64. doi: 10.1177/096032718900800505.
Methylene blue, at high concentrations, interferes with the estimation of methaemoglobin using the IL 282 CO-oximeter: the dye does not interfere with the method of Evelyn & Malloy for determination of methaemoglobin. In beagle bitches methylene blue causes both methaemoglobinogenesis and methaemoglobin reduction, the effect of the former being to delay the decline of methaemoglobin levels, when methylene blue is used to reverse the methaemoglobinaemia produced by sodium nitrite.
高浓度的亚甲蓝会干扰使用IL 282型一氧化碳血氧计对高铁血红蛋白的测定：该染料不会干扰伊夫林和马洛伊测定高铁血红蛋白的方法。在比格犬母犬中，亚甲蓝会导致高铁血红蛋白生成和高铁血红蛋白还原，当使用亚甲蓝来逆转由亚硝酸钠产生的高铁血红蛋白血症时，前者的作用是延迟高铁血红蛋白水平的下降。
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