Ayub Shahana, Saboor Sundas, Usmani Sadia, Javed Sana, Tonpouwo Gauvain Kankeu, Ahmed Saeed
Psychiatrist, Cornerstone Family Health, Newburgh, New York.
Physician, Khyber Medical College, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Ment Health Clin. 2022 Jun 10;12(3):214-218. doi: 10.9740/mhc.2022.06.214. eCollection 2022 Jun.
Lithium is among the mainstays of treatment for bipolar disorder. Bariatric surgery can considerably change the oral bioavailability of drugs, particularly lithium. In this review, a 36-year-old male patient is described, who presented with lithium toxicity, including neurologic and gastric symptoms after undergoing Roux-en-Y gastric bypass. The mechanism of lithium toxicity is discussed; recommendations for clinicians regarding lithium use in postsurgical patients are provided; and previous case reports of lithium toxicity post-gastric bypass surgery are analyzed. Awareness and education of lithium absorption changes postbariatric surgery is essential for optimal patient care. Close clinical and drug concentration level monitoring is warranted.
锂是双相情感障碍治疗的主要药物之一。减肥手术会显著改变药物的口服生物利用度，尤其是锂。在本综述中，描述了一名36岁男性患者，他在接受Roux-en-Y胃旁路手术后出现锂中毒，包括神经和胃部症状。讨论了锂中毒的机制；为临床医生提供了关于锂在术后患者中使用的建议；并分析了先前胃旁路手术后锂中毒的病例报告。了解减肥手术后锂吸收的变化并进行教育对于优化患者护理至关重要。有必要进行密切的临床和药物浓度水平监测。
