Massachusetts General Hospital and Harvard Medical School, 50 Staniford Street, 4th Floor, Boston, MA, 02114, USA.
Curr Obes Rep. 2018 Dec;7(4):294-300. doi: 10.1007/s13679-018-0322-y.
Bipolar disorder (BD) is a severe, common, and chronic affective disorder. This review highlights the BD and obesity connection and the role of treatments for obesity in this population.
Patients with BD are at a significantly increased risk for obesity, as compared to those without BD, with obesity serving as a proxy for severity and predictor of poorer outcome. BD is characterized by substantial medical burden, with obesity-related conditions contributing to premature mortality. Pharmacotherapy for BD can cause weight gain and may be moderated by binge eating behavior. Bariatric surgery may be the most robust intervention for weight loss in patients with stable BD, but access may be limited. There is a greater need for interventions to prevent weight gain in BD, the development weight-neutral medications for BD, and more research into the role of bariatric surgery for patients with BD.
双相情感障碍（BD）是一种严重、常见且慢性的情感障碍。本综述强调了 BD 与肥胖之间的联系，以及治疗肥胖在这一人群中的作用。
与没有 BD 的人相比，BD 患者患肥胖症的风险显著增加，肥胖症是严重程度的代表，也是预后较差的预测指标。BD 具有很大的医疗负担，肥胖相关疾病导致过早死亡。BD 的药物治疗会导致体重增加，而暴食行为可能会影响体重增加的程度。对于病情稳定的 BD 患者，减重手术可能是最有效的减肥干预措施，但可能会受到限制。因此，更需要针对 BD 预防体重增加的干预措施、开发用于 BD 的体重中性药物，以及更多研究减重手术在 BD 患者中的作用。
