Wolgin D L, Thompson G B, Oslan I A
Behav Neurosci. 1987 Apr;101(2):264-71. doi: 10.1037//0735-7044.101.2.264.
In this article, the effect of chronic injections of amphetamine on feeding and behavioral activation was analyzed. Rats were given milk either through an intraoral cannula or in a standard drinking tube, and the level of their behavioral activation was monitored before, during, and after access to the milk. Cannula- and bottle-fed rats given saline showed similar patterns of intake and activity. Bottle-fed rats given amphetamine (2 mg/kg) showed substantially greater suppression of intake than did cannula-fed rats, but recovered more rapidly, confirming earlier findings (Salisbury & Wolgin, 1985). Such recovery was accompanied by a suppression of stereotyped head scanning movements during access to milk, but not before and after milk access. In contrast, cannula-fed rats given amphetamine showed stereotyped head scans throughout the session for the duration of the experiment. These results suggest that tolerance to the suppression of intake by amphetamine involves learning to suppress stereotyped head movements. The constraints on such learning are briefly discussed.
在本文中，分析了长期注射苯丙胺对进食和行为激活的影响。通过口腔内插管或标准饮水管给大鼠喂牛奶，并在获取牛奶之前、期间和之后监测它们的行为激活水平。给予生理盐水的插管喂养和奶瓶喂养的大鼠表现出相似的摄入和活动模式。给予苯丙胺（2毫克/千克）的奶瓶喂养大鼠比插管喂养大鼠表现出对摄入的抑制作用明显更大，但恢复得更快，这证实了早期的研究结果（索尔兹伯里和沃尔金，1985年）。这种恢复伴随着在获取牛奶期间刻板的头部扫描动作的抑制，但在获取牛奶之前和之后没有。相比之下，给予苯丙胺的插管喂养大鼠在整个实验过程中都表现出刻板的头部扫描。这些结果表明，对苯丙胺抑制摄入的耐受性涉及学会抑制刻板的头部动作。简要讨论了这种学习的限制因素。
